Relationship between PFA-100 closure time and study parameters
. | Collagen + ADP* . | Collagen + epinephrine†closure time (± 2 SD) 139 s (± 68) n = 102 . |
|---|---|---|
| GPVI levels | ||
| P | .0052‡ | .0131‡ |
| r | -0.28 | -0.24 |
| R2 | 0.076 | 0.060 |
| α2 integrin levels | ||
| P | .5939 | .5442 |
| r | -0.53 | -0.06 |
| R2 | 0.003 | 0.004 |
| GPIb levels | ||
| P | .4654 | .1644 |
| r | -0.073 | -0.14 |
| R2 | 0.005 | 0.019 |
| CD36 levels | ||
| P | .8526 | .3541 |
| r | -0.019 | -0.092 |
| R2 | 0.0003 | 0.009 |
| von Willebrand factor | ||
| P | <.0001‡ | <.0001‡ |
| r | -0.497 | -0.388 |
| R2 | 0.246 | 0.1512 |
| Mean platelet volume | ||
| P | .0192‡ | .0047‡ |
| r | -0.232 | -0.278 |
| R2 | 0.054 | 0.077 |
. | Collagen + ADP* . | Collagen + epinephrine†closure time (± 2 SD) 139 s (± 68) n = 102 . |
|---|---|---|
| GPVI levels | ||
| P | .0052‡ | .0131‡ |
| r | -0.28 | -0.24 |
| R2 | 0.076 | 0.060 |
| α2 integrin levels | ||
| P | .5939 | .5442 |
| r | -0.53 | -0.06 |
| R2 | 0.003 | 0.004 |
| GPIb levels | ||
| P | .4654 | .1644 |
| r | -0.073 | -0.14 |
| R2 | 0.005 | 0.019 |
| CD36 levels | ||
| P | .8526 | .3541 |
| r | -0.019 | -0.092 |
| R2 | 0.0003 | 0.009 |
| von Willebrand factor | ||
| P | <.0001‡ | <.0001‡ |
| r | -0.497 | -0.388 |
| R2 | 0.246 | 0.1512 |
| Mean platelet volume | ||
| P | .0192‡ | .0047‡ |
| r | -0.232 | -0.278 |
| R2 | 0.054 | 0.077 |
Closure time was measured in citrated whole blood within 4 hours of venepuncture using 2 cartridges, 1 with collagen and epinephrine and 1 with collagen and ADP. PFA-100 closure time was inversely correlated to VWF antigen levels, and a weak relationship was also indicated with MPV and GPVI levels.
Mean closure time of 92 ± 40 seconds (mean ± 2 SD); n = 102.
Mean closure time of 139 ± 68 seconds (mean ± 2 SD); n = 102.
Statistically significant at P < .05.