Peripheral blood myeloid progenitor cell mobilizing effects of AMD-3100 (80 μg/kg SC) in healthy human volunteers
. | Myeloid progenitor cells (fold change from Time = 0 h) . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| . | Agar CFU-GMs . | Methylcellulose . | . | . | |||
| Time, h . | . | CFU-GMs . | BFU-Es . | CFU-GEMMs . | |||
| 1 | 2.8 ± 0.3* | 4.9 ± 0.5* | 2.1 ± 0.2* | 2.6 ± 0.3* | |||
| 3 | 8.5 ± 0.3* | 11.3 ± 1.6* | 3.2 ± 0.3* | 5.1 ± 0.8* | |||
| 6 | 17.9 ± 0.7* | 19.7 ± 2.4* | 5.5 ± 0.7* | 9.7 ± 1.4* | |||
| 9 | 10.3 ± 2.0* | 8.9 ± 1.1* | 3.8 ± 0.3* | 4.5 ± 0.8* | |||
| 24 | 2.1 ± 1.0 | 1.4 ± 0.1* | 1.2 ± 0.1 | 1.3 ± 0.2 | |||
. | Myeloid progenitor cells (fold change from Time = 0 h) . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| . | Agar CFU-GMs . | Methylcellulose . | . | . | |||
| Time, h . | . | CFU-GMs . | BFU-Es . | CFU-GEMMs . | |||
| 1 | 2.8 ± 0.3* | 4.9 ± 0.5* | 2.1 ± 0.2* | 2.6 ± 0.3* | |||
| 3 | 8.5 ± 0.3* | 11.3 ± 1.6* | 3.2 ± 0.3* | 5.1 ± 0.8* | |||
| 6 | 17.9 ± 0.7* | 19.7 ± 2.4* | 5.5 ± 0.7* | 9.7 ± 1.4* | |||
| 9 | 10.3 ± 2.0* | 8.9 ± 1.1* | 3.8 ± 0.3* | 4.5 ± 0.8* | |||
| 24 | 2.1 ± 1.0 | 1.4 ± 0.1* | 1.2 ± 0.1 | 1.3 ± 0.2 | |||
Values are expressed as mean ± SEM; n = 10.
P < .005 compared with baseline (Time = 0 h).