Complications of hematopoietic stem cell transplantation
Patient . | Last follow-up, years after HSCT . | Change in EDSS from before HSCT to last follow-up . | Infections . | Other events . |
|---|---|---|---|---|
| 1 | 5 | 8.0 to 9.0 | Dermatomal zoster | Engraftment syndrome.* Transient asymptomatic hypotension |
| 2 | 5 | 8.5 to 9.0 | None | None |
| 3 | 3 | 7.0 to 8.5 | Urine Klebsiella, dermatomal zoster, sinusitis | Asymptomatic subdural hematoma |
| 4 | 4 | 8.0 to 8.0 | Blood Pseudomonas aeruginosa bacteremia | G-CSF-associated disease flare during mobilization |
| 5 | 4 | 8.0 to 9.0 | None | None |
| 6 | Died at 18 mo | 8.0 to 10 | None | Traumatic intracerebral hemorrhage. Died 18 months after HSCT from complications of progressive disease |
| 7 | 2 | 6.5 to 7.5 | None | Failure to thrive requiring enteral feeding |
| 8 | 2 | 7.0 to 7.0 | None | None |
| 9 | 6 mo | 7.5 to 9.0 | None | Engraftment syndrome* |
| 10 | 2 | 3.0 to 3.5 | None | None |
| 11 | 1 | 3.5 to 3.5 | None | None |
| 12 | 2 | 7.0 to 8.0 | Disseminated varicella zoster at 20 mo | Acute flare of MS at 14 months |
| 13 | Died 13 mo | 7.0 to 10 | None | Engraftment syndrome.* Transient asymptomatic hypotension. Died 13 months after HSCT from complications of progressive disease |
| 14 | 1 | 5.5 to 6.0 | None | None |
| 15 | 1 | 6.0 to 6.5 | None | Engraftment syndrome* |
| 16 | 2 | 3.5 to 1.0 | None | Atrial fibrillation from central line |
| 17 | 1 | 5.5 to 6.0 | None | Mild hemorrhagic cystitis |
| 18 | 1 | 7.0 to 7.5 | Clostridium difficule diarrhea | Engraftment syndrome,* transient asymptomatic hypotension |
| 19 | 1 | 6.0 to 6.0 | None | Peritransplantation vaginal bleeding, vaginal bleeding engraftment syndrome |
| 20 | 1 | 5.0 to 5.5 | None | None |
| 21 | 1 | 6.0 to 6.5 | None | Deep venous thrombosis and pulmonary emboli 2 mo after HSCT |
Patient . | Last follow-up, years after HSCT . | Change in EDSS from before HSCT to last follow-up . | Infections . | Other events . |
|---|---|---|---|---|
| 1 | 5 | 8.0 to 9.0 | Dermatomal zoster | Engraftment syndrome.* Transient asymptomatic hypotension |
| 2 | 5 | 8.5 to 9.0 | None | None |
| 3 | 3 | 7.0 to 8.5 | Urine Klebsiella, dermatomal zoster, sinusitis | Asymptomatic subdural hematoma |
| 4 | 4 | 8.0 to 8.0 | Blood Pseudomonas aeruginosa bacteremia | G-CSF-associated disease flare during mobilization |
| 5 | 4 | 8.0 to 9.0 | None | None |
| 6 | Died at 18 mo | 8.0 to 10 | None | Traumatic intracerebral hemorrhage. Died 18 months after HSCT from complications of progressive disease |
| 7 | 2 | 6.5 to 7.5 | None | Failure to thrive requiring enteral feeding |
| 8 | 2 | 7.0 to 7.0 | None | None |
| 9 | 6 mo | 7.5 to 9.0 | None | Engraftment syndrome* |
| 10 | 2 | 3.0 to 3.5 | None | None |
| 11 | 1 | 3.5 to 3.5 | None | None |
| 12 | 2 | 7.0 to 8.0 | Disseminated varicella zoster at 20 mo | Acute flare of MS at 14 months |
| 13 | Died 13 mo | 7.0 to 10 | None | Engraftment syndrome.* Transient asymptomatic hypotension. Died 13 months after HSCT from complications of progressive disease |
| 14 | 1 | 5.5 to 6.0 | None | None |
| 15 | 1 | 6.0 to 6.5 | None | Engraftment syndrome* |
| 16 | 2 | 3.5 to 1.0 | None | Atrial fibrillation from central line |
| 17 | 1 | 5.5 to 6.0 | None | Mild hemorrhagic cystitis |
| 18 | 1 | 7.0 to 7.5 | Clostridium difficule diarrhea | Engraftment syndrome,* transient asymptomatic hypotension |
| 19 | 1 | 6.0 to 6.0 | None | Peritransplantation vaginal bleeding, vaginal bleeding engraftment syndrome |
| 20 | 1 | 5.0 to 5.5 | None | None |
| 21 | 1 | 6.0 to 6.5 | None | Deep venous thrombosis and pulmonary emboli 2 mo after HSCT |
—indicates not applicable.
Engraftment syndrome is rash, fever, and fatigue.30 Patients listed by order of enrollment on study.