Table 4.

Top 50 of 157 most differentially expressed genes in a comparison of N-ras-activating mutation and stroma response

Accession no.
Gene symbol
Function
Fold difference in geometric means
F test P
Up-regulated     
X02751 HSNRASR  Oncogene   304.88   .000274  
AI142565 RNASE 6  Transcription   78.79   2.26 × 10−5 
U20350 V28  G protein-coupled receptor   29.09   .000275  
AI660656 EST  Unknown   23.69   5.34 × 10−6 
U04343 CD86  Costimulatory signal   12.62   .000805  
AF070641 IGJ  Immunity   12.42   .000308  
AF043722 Rap2  GEF/signaling   12.03   9.71 × 10−5 
D21205 ERFP  Ubiquitin ligase/cell cycle   11.65   6 × 10−5 
S71326 BGPc/CEACAM1  Adhesion   11.56   3.86 × 10−5 
X81438 amphiphysin  Synaptic vesicle protein   11.38   .000535  
X04011 CGD  Metabolism   10.50   .000728  
Y14737 IGHM  Immunity   9.68   .000561  
AB013382 DUSP6  Signaling   9.52   6.95 × 10−5 
U48807 DUSP4  Signaling   9.28   9.37 × 10−5 
AL512715 GEF2  Signaling   8.98   3.14 × 10−6 
Z54367 PLECTIN  Cytoskeleton   8.84   .000168  
AB020689 KIAA0882  Unknown   8.45   .000161  
M55067 NCF1  Metabolism   7.69   9.12 × 10−6 
J04430 ACP5  Metabolism   7.42   .000149  
AF055004 EST  Unknown   7.00   .000496  
AB018278 SVB2  Synaptic vesicle transporter   6.96   .000573  
AB002351 DMN  Cytoskeleton   6.85   .000287  
M80335 p47-phox  Metabolism   6.78   .000483  
M62397 MCC  Tumor supressor   6.62   .00057  
X99802 ZYG  Unknown   6.34   3.46 × 10−5 
Down-regulated     
V01512 cFos  Oncogene   304.43   3.38 × 10−6 
M77349 TGFBI  Adhesion   140.46   .000748  
M12125 TPM2  Cytoskeleton   77.33   .000394  
X78947 IGFBP8  Signaling   67.11   3.58 × 10−5 
X04430 IL-6  Cytokine   64.43   .000822  
J03464 COL1A2  ECM   56.21   .000724  
K00650 c-Fos  Oncogene   54.48   1.84 × 10−5 
D13666 OSF-2  ECM   52.91   3.28 × 10−5 
J03040 Sparc  ECM   49.84   7.16 × 10−5 
X52022 COL6A3  ECM   45.36   .000489  
S77154 NR4A2  Signaling   38.75   3.19 × 10−7 
X13839 ACTSA  Cytoskeleton   33.11   .00033  
U03057 FSCN1  Cytoskeleton   30.31   .000256  
M19267 TPM1  Cytoskeleton   29.27   3.27 × 10−5 
X52947 GJA1  Gap junction   29.03   .000323  
X68277 DUSP1  Signaling   27.11   4.62 × 10−5 
M17733 TMSB4  Cytoskeleton   23.31   .000299  
L19182 IGFBP7  Signaling   21.15   .00024  
M35878 IGFBP3  Signaling   19.38   .000308  
X75918 NR4A2  Signaling   19.09   .000212  
AB029000 SULF1  Metabolism   18.51   9.69 × 10−5 
AI557295 EST  Unknown   15.75   .000395  
M58459 RPS4X  Translation   12.56   .000231  
M33680
 		CD81
 		 Membrane protein
 		 11.87
 		 .000117
 
Accession no.
Gene symbol
Function
Fold difference in geometric means
F test P
Up-regulated     
X02751 HSNRASR  Oncogene   304.88   .000274  
AI142565 RNASE 6  Transcription   78.79   2.26 × 10−5 
U20350 V28  G protein-coupled receptor   29.09   .000275  
AI660656 EST  Unknown   23.69   5.34 × 10−6 
U04343 CD86  Costimulatory signal   12.62   .000805  
AF070641 IGJ  Immunity   12.42   .000308  
AF043722 Rap2  GEF/signaling   12.03   9.71 × 10−5 
D21205 ERFP  Ubiquitin ligase/cell cycle   11.65   6 × 10−5 
S71326 BGPc/CEACAM1  Adhesion   11.56   3.86 × 10−5 
X81438 amphiphysin  Synaptic vesicle protein   11.38   .000535  
X04011 CGD  Metabolism   10.50   .000728  
Y14737 IGHM  Immunity   9.68   .000561  
AB013382 DUSP6  Signaling   9.52   6.95 × 10−5 
U48807 DUSP4  Signaling   9.28   9.37 × 10−5 
AL512715 GEF2  Signaling   8.98   3.14 × 10−6 
Z54367 PLECTIN  Cytoskeleton   8.84   .000168  
AB020689 KIAA0882  Unknown   8.45   .000161  
M55067 NCF1  Metabolism   7.69   9.12 × 10−6 
J04430 ACP5  Metabolism   7.42   .000149  
AF055004 EST  Unknown   7.00   .000496  
AB018278 SVB2  Synaptic vesicle transporter   6.96   .000573  
AB002351 DMN  Cytoskeleton   6.85   .000287  
M80335 p47-phox  Metabolism   6.78   .000483  
M62397 MCC  Tumor supressor   6.62   .00057  
X99802 ZYG  Unknown   6.34   3.46 × 10−5 
Down-regulated     
V01512 cFos  Oncogene   304.43   3.38 × 10−6 
M77349 TGFBI  Adhesion   140.46   .000748  
M12125 TPM2  Cytoskeleton   77.33   .000394  
X78947 IGFBP8  Signaling   67.11   3.58 × 10−5 
X04430 IL-6  Cytokine   64.43   .000822  
J03464 COL1A2  ECM   56.21   .000724  
K00650 c-Fos  Oncogene   54.48   1.84 × 10−5 
D13666 OSF-2  ECM   52.91   3.28 × 10−5 
J03040 Sparc  ECM   49.84   7.16 × 10−5 
X52022 COL6A3  ECM   45.36   .000489  
S77154 NR4A2  Signaling   38.75   3.19 × 10−7 
X13839 ACTSA  Cytoskeleton   33.11   .00033  
U03057 FSCN1  Cytoskeleton   30.31   .000256  
M19267 TPM1  Cytoskeleton   29.27   3.27 × 10−5 
X52947 GJA1  Gap junction   29.03   .000323  
X68277 DUSP1  Signaling   27.11   4.62 × 10−5 
M17733 TMSB4  Cytoskeleton   23.31   .000299  
L19182 IGFBP7  Signaling   21.15   .00024  
M35878 IGFBP3  Signaling   19.38   .000308  
X75918 NR4A2  Signaling   19.09   .000212  
AB029000 SULF1  Metabolism   18.51   9.69 × 10−5 
AI557295 EST  Unknown   15.75   .000395  
M58459 RPS4X  Translation   12.56   .000231  
M33680
 		CD81
 		 Membrane protein
 		 11.87
 		 .000117
 

GEF indicates guanine exchange factor.

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