Table 3.

Top 50 of 130 most differentially expressed genes in a comparison of N-ras-activating mutation and IL-6 response

Accession no.
Gene symbol
Function
Fold difference in geometric means
F test P
Up-regulated     
X02751  HSNRASR  Oncogene   52.41   3.41 × 10−7 
AI142565  RNASE6  Transcription   34.33   4.4 × 10−7 
Y14737  IGHM  Immunity   27.78   .000209  
J04130  Act-2/(MIP-1β)  Chemokine   16.43   1.28 × 10−5 
M37766  MEM-102  B-cell activation   12.08   2.24 × 10−5 
AB013382  DUSP6  Sinaling   11.37   .000243  
U20350  V28  G protein-coupled receptor   11.03   .000866  
U33147  MGB1  ECM   9.21   .000391  
D90144  LD78  Chemokine/osteoclastogenic factor   6.79   2.16 × 10−5 
AL040446  ORP1  Drug metabalism   6.38   .000642  
D13265  MSR1  Macrophage scavenger receptor   6.31   4.15 × 10−5 
AI660656  IGJ  Immunity   6.17   7.47 × 10−5 
AB018278  SV2B  Synaptic vesicle transporter   5.77   .000259  
X16354  BGPa/CEACAM1  Adhesion/angiogenesis   5.95   .000253  
AL023653  XPNPEP2  ECM   5.57   .000697  
M15059  IgE receptor  Immunity   5.5   8.44 × 10−6 
AB020499  MD-1  B-cell activation   5.21   .000214  
U04343  CD86  Costimulatory signal/immunity   5.2   2.16 × 10−5 
M24594  IFIT1  Unknown   5.15   .000881  
AI535946  LGALS1  Cell cycle inhibition   4.99   1.92 × 10−5 
AF093265  homer-3  Calcium release   4.34   .000621  
M32011  NSF2  Metabolism   4.23   .000254  
X04011  CGD  Metabolism   3.96   2 × 10−4 
NP001060  Tubulin beta  Cytoskeleton   3.87   .000952  
M21121  RANTES  Chemokine/immunity   3.8   .000289  
Down-regulated     
AB023180  KIAA0963  Unknown   9.08   .000675  
AB017430  KNSL4  Mitosis   8.31   .000264  
L41668  Gale  Metabolism   7.75   4.33 × 10−5 
AI391564  PTP4A3  Signaling   7.38   .000179  
M80397  POLD1  DNA replication   7.36   .000337  
AF091754  EXO1  DNA repair   5.24   6.93 × 10−5 
M25753  cyclin B1  Cell cycle   4.85   .000496  
U73379  E2C  Ubiquination   4.63   2.78 × 10−5 
U77949  CDC6  Cell cycle control   4.55   1.89 × 10−5 
X62048  WEE1  Cell cycle control   4.31   .000138  
L25876  CDKN3  Cell cycle control   4.27   2.54 × 10−5 
U77845  hTRIP  Signaling   4.15   .000402  
U05340  CDC20  Cell cycle control   4.13   .00014  
M34065  CDC25C  Cell cycle   4.09   .0000294  
X13293  B-myb  Oncogene   4.06   3.81 × 10−6 
AF025441  OIP5  Adhesion/invasion   4.02   .000414  
U14518  CENPA  Cell division   4.00   .000269  
U74612  FKHL16  Transcription factor   3.91   6.59 × 10−5 
U63743  KNSL6  Mitosis   3.89   .000552  
AL080146  cyclin B2  Cell cycle   3.88   .000243  
D38073  MCM3  DNA replication   3.77   .000107  
AF053306  BUB3  Cell cycle control   3.77   3.52 × 10−6 
X65550  MK167  Cell cycle   3.76   .000159  
X05360  CDC2  Cell cycle   3.75   .00099  
N58115
 		AD024
 		 Unknown
 		 3.75
 		 .000115
 
Accession no.
Gene symbol
Function
Fold difference in geometric means
F test P
Up-regulated     
X02751  HSNRASR  Oncogene   52.41   3.41 × 10−7 
AI142565  RNASE6  Transcription   34.33   4.4 × 10−7 
Y14737  IGHM  Immunity   27.78   .000209  
J04130  Act-2/(MIP-1β)  Chemokine   16.43   1.28 × 10−5 
M37766  MEM-102  B-cell activation   12.08   2.24 × 10−5 
AB013382  DUSP6  Sinaling   11.37   .000243  
U20350  V28  G protein-coupled receptor   11.03   .000866  
U33147  MGB1  ECM   9.21   .000391  
D90144  LD78  Chemokine/osteoclastogenic factor   6.79   2.16 × 10−5 
AL040446  ORP1  Drug metabalism   6.38   .000642  
D13265  MSR1  Macrophage scavenger receptor   6.31   4.15 × 10−5 
AI660656  IGJ  Immunity   6.17   7.47 × 10−5 
AB018278  SV2B  Synaptic vesicle transporter   5.77   .000259  
X16354  BGPa/CEACAM1  Adhesion/angiogenesis   5.95   .000253  
AL023653  XPNPEP2  ECM   5.57   .000697  
M15059  IgE receptor  Immunity   5.5   8.44 × 10−6 
AB020499  MD-1  B-cell activation   5.21   .000214  
U04343  CD86  Costimulatory signal/immunity   5.2   2.16 × 10−5 
M24594  IFIT1  Unknown   5.15   .000881  
AI535946  LGALS1  Cell cycle inhibition   4.99   1.92 × 10−5 
AF093265  homer-3  Calcium release   4.34   .000621  
M32011  NSF2  Metabolism   4.23   .000254  
X04011  CGD  Metabolism   3.96   2 × 10−4 
NP001060  Tubulin beta  Cytoskeleton   3.87   .000952  
M21121  RANTES  Chemokine/immunity   3.8   .000289  
Down-regulated     
AB023180  KIAA0963  Unknown   9.08   .000675  
AB017430  KNSL4  Mitosis   8.31   .000264  
L41668  Gale  Metabolism   7.75   4.33 × 10−5 
AI391564  PTP4A3  Signaling   7.38   .000179  
M80397  POLD1  DNA replication   7.36   .000337  
AF091754  EXO1  DNA repair   5.24   6.93 × 10−5 
M25753  cyclin B1  Cell cycle   4.85   .000496  
U73379  E2C  Ubiquination   4.63   2.78 × 10−5 
U77949  CDC6  Cell cycle control   4.55   1.89 × 10−5 
X62048  WEE1  Cell cycle control   4.31   .000138  
L25876  CDKN3  Cell cycle control   4.27   2.54 × 10−5 
U77845  hTRIP  Signaling   4.15   .000402  
U05340  CDC20  Cell cycle control   4.13   .00014  
M34065  CDC25C  Cell cycle   4.09   .0000294  
X13293  B-myb  Oncogene   4.06   3.81 × 10−6 
AF025441  OIP5  Adhesion/invasion   4.02   .000414  
U14518  CENPA  Cell division   4.00   .000269  
U74612  FKHL16  Transcription factor   3.91   6.59 × 10−5 
U63743  KNSL6  Mitosis   3.89   .000552  
AL080146  cyclin B2  Cell cycle   3.88   .000243  
D38073  MCM3  DNA replication   3.77   .000107  
AF053306  BUB3  Cell cycle control   3.77   3.52 × 10−6 
X65550  MK167  Cell cycle   3.76   .000159  
X05360  CDC2  Cell cycle   3.75   .00099  
N58115
 		AD024
 		 Unknown
 		 3.75
 		 .000115
 
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