Table 2.

Top 50 of 87 most differentially expressed genes in a comparison of stroma stimulation and IL-6 response

Accession no.
Gene symbol
Function
Fold difference in geometric means
F test P
Up-regulated     
X78947 IGFBP8  Growth factor   123.88   5.13 × 10−5 
M77349 TGFBIG  Adhesion/ECM   121.08   5.25 × 10−5 
V01512 cFos  Oncogene   91.72   8.02 × 10−8 
X04430 IFN-β2A  Growth factor   76.19   .000492  
J03040 SPARC/osteonectin  ECM   56.96   7.97 × 10−5 
M12125 tropomyosin/TPM2  Cytoskeleton   56.47   3.91 × 10−5 
J03464 CO1A2  ECM   45.27   .000677  
X15998 versican  ECM   42.57   1.78 × 10−5 
K00650 cFos  Oncogene   41.98   1.86 × 10−5 
V00503 CO1A2  ECM   38.02   4.84 × 10−5 
X68277 CL100  Signaling   34.36   3.22 × 10−6 
U24389 LOXL1  Metabolism   31.69   9.37 × 10−6 
M17733 TMSB4X  Cytoskeleton   30.18   .000114  
X52022 COL6A3  ECM   28.31   2.56 × 10−5 
X13839 ACTSA  Cytoskeleton   27.78   9.71 × 10−5 
S77154 NR4A2  Transcription factor   22.62   1.44 × 10−6 
M35878 IGFBP3  Angiogenesis   20.92   .000238  
L12350 THBS2  ECM   16.81   .000253  
M19267 TPM1  Cytoskeleton   16.64   .000244  
U03057 HSN  Cytoskeleton   15.98   .000723  
U08021 NNMT  Metabolism   15.79   .000352  
M55153 TGM2  Metabolism   14.42   .000228  
S81914 IER3  Transcription factor   14.08   .000231  
J04130 Act-2/(MIP-1β)  Chemokine   13.67   6.8 × 10−7 
L19182 IGFBP4  IGF regulation/growth   13.59   .000327  
M36820 GRO-β  Chemokine   11.09   .000229  
AB029000 KIAA1077  Unknown   10.96   9.56 × 10−5 
S78569 LAMA 4  ECM   10.58   .000138  
M14083 PAI 1  ECM   10.52   .000262  
U97669 NOTCH 3  Signaling   10.09   5.05 × 10−6 
M27830 28S ribosomal RNA  Translation   9.9   .000126  
L49169 RGS2  Cell cycle   9.74   .000186  
L13463 GOS3  Cell cycle   9.59   .000949  
AB018293 KIAA0750  Unknown   9.16   .000933  
M58459 RPS4Y  Translation   9.16   .000423  
S59049 RGS1  B-cell activation   8.99   .000579  
D32039 CSPG2  Proteoglycan/ECM   8.89   .000748  
D90144 LD78/Mip-1α  Osteoclastogenic factor/chemokine   8.86   1.87 × 10−5 
AF052119 EST  Unknown   8.13   .000464  
AL096713 EST  Unknown   8.10   .000728  
AI246894 EST  Unknown   7.87   .000453  
AF056085 GPR 51  GABA receptor   7.71   .000891  
X15880 COL6A1  ECM   7.50   .000988  
M69043 NFKBIA  Signaling   7.11   4.57 × 10−6 
L16895 LOX  Metabolism   6.87   .000644  
Down-regulated     
AJ001612 PSPHL  Signaling   3.50   4.69 × 10−5 
S68805 GATM  Metabolism   2.66   1.24 × 10−5 
M55067 CGD  Metabolism   2.32   .00083  
U77949 CDC6  Cell cycle   2.19   6.47 × 10−5 
AB014597
 		KIAA0697
 		 Unknown
 		 2.12
 		 .000558
 
Accession no.
Gene symbol
Function
Fold difference in geometric means
F test P
Up-regulated     
X78947 IGFBP8  Growth factor   123.88   5.13 × 10−5 
M77349 TGFBIG  Adhesion/ECM   121.08   5.25 × 10−5 
V01512 cFos  Oncogene   91.72   8.02 × 10−8 
X04430 IFN-β2A  Growth factor   76.19   .000492  
J03040 SPARC/osteonectin  ECM   56.96   7.97 × 10−5 
M12125 tropomyosin/TPM2  Cytoskeleton   56.47   3.91 × 10−5 
J03464 CO1A2  ECM   45.27   .000677  
X15998 versican  ECM   42.57   1.78 × 10−5 
K00650 cFos  Oncogene   41.98   1.86 × 10−5 
V00503 CO1A2  ECM   38.02   4.84 × 10−5 
X68277 CL100  Signaling   34.36   3.22 × 10−6 
U24389 LOXL1  Metabolism   31.69   9.37 × 10−6 
M17733 TMSB4X  Cytoskeleton   30.18   .000114  
X52022 COL6A3  ECM   28.31   2.56 × 10−5 
X13839 ACTSA  Cytoskeleton   27.78   9.71 × 10−5 
S77154 NR4A2  Transcription factor   22.62   1.44 × 10−6 
M35878 IGFBP3  Angiogenesis   20.92   .000238  
L12350 THBS2  ECM   16.81   .000253  
M19267 TPM1  Cytoskeleton   16.64   .000244  
U03057 HSN  Cytoskeleton   15.98   .000723  
U08021 NNMT  Metabolism   15.79   .000352  
M55153 TGM2  Metabolism   14.42   .000228  
S81914 IER3  Transcription factor   14.08   .000231  
J04130 Act-2/(MIP-1β)  Chemokine   13.67   6.8 × 10−7 
L19182 IGFBP4  IGF regulation/growth   13.59   .000327  
M36820 GRO-β  Chemokine   11.09   .000229  
AB029000 KIAA1077  Unknown   10.96   9.56 × 10−5 
S78569 LAMA 4  ECM   10.58   .000138  
M14083 PAI 1  ECM   10.52   .000262  
U97669 NOTCH 3  Signaling   10.09   5.05 × 10−6 
M27830 28S ribosomal RNA  Translation   9.9   .000126  
L49169 RGS2  Cell cycle   9.74   .000186  
L13463 GOS3  Cell cycle   9.59   .000949  
AB018293 KIAA0750  Unknown   9.16   .000933  
M58459 RPS4Y  Translation   9.16   .000423  
S59049 RGS1  B-cell activation   8.99   .000579  
D32039 CSPG2  Proteoglycan/ECM   8.89   .000748  
D90144 LD78/Mip-1α  Osteoclastogenic factor/chemokine   8.86   1.87 × 10−5 
AF052119 EST  Unknown   8.13   .000464  
AL096713 EST  Unknown   8.10   .000728  
AI246894 EST  Unknown   7.87   .000453  
AF056085 GPR 51  GABA receptor   7.71   .000891  
X15880 COL6A1  ECM   7.50   .000988  
M69043 NFKBIA  Signaling   7.11   4.57 × 10−6 
L16895 LOX  Metabolism   6.87   .000644  
Down-regulated     
AJ001612 PSPHL  Signaling   3.50   4.69 × 10−5 
S68805 GATM  Metabolism   2.66   1.24 × 10−5 
M55067 CGD  Metabolism   2.32   .00083  
U77949 CDC6  Cell cycle   2.19   6.47 × 10−5 
AB014597
 		KIAA0697
 		 Unknown
 		 2.12
 		 .000558
 

IGF indicates insulin-like growth factor; GABA, γ-aminobutyric acid.

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