Analysis of functional IgVH gene rearrangements in monoclonal B-cell PTLDs
Case . | Histology . | IgVH family . | Closest IgVH germline gene . | % of mutation . | D . | JH . |
|---|---|---|---|---|---|---|
| 2614 | P-PTLD | VH3 | 3-74 | GL | NA | JH4b/JH5b |
| 2618 | P-PTLD | VH3 | 3-30.3 | 5.64 | D4-23 | JH6b |
| 2916 | P-PTLD | VH5 | 5-51 | 2.77 | NA | JH3b |
| 3464 | P-PTLD | VH3 | 3-15 | GL | NA | JH3b |
| 3468 | P-PTLD | VH3 | 3-07 | 12.3 | D5-18/D5-5 | JH6a |
| 3471 | P-PTLD | VH3 | 3-30 | 12.1 | D3-3 | JH6b |
| 3515 | P-PTLD | VH3 | 3-15 | 10.3 | NA | JH4b |
| 3519 | P-PTLD | VH3 | 3-30 | 10.3 | D3-22 | JH4b |
| 2798 | DLBCL, centroblastic | VH4 | 4-34 | 23.2 | NA | JH3a/JH6 |
| 2898 | DLBCL, centroblastic | VH4 | 4-34 | 11.8 | NA | JH4b |
| 2912 | DLBCL, centroblastic | VH5 | 5-51 | 4.06 | D6-19 | JH4b |
| 2914 | DLBCL, centroblastic | VH3 | 3-74 | 8.64 | D1-7 | JH4b |
| 3459 | DLBCL, centroblastic | VH1 | 1-69 | 17.6 | D3-10 | JH4d |
| 3466 | DLBCL, centroblastic | VH3 | 1-f | 3.73 | D6-19 | JH4b |
| 3467 | DLBCL, centroblastic | VH2 | S12-7 | GL | D6-25 | JH3b |
| 3518 | DLBCL, centroblastic | VH3 | 3-33 | 4.41 | D5-5/D5-18 | JH4/JH5 |
| 3522 | DLBCL, centroblastic | VH4 | 4-34 | 6.87 | D3-3 | JH3b |
| 3523 | DLBCL, centroblastic | VH1 | 1-46 | 2.71 | D4-23 | JH4b |
| 3524 | DLBCL, centroblastic | VH3 | 3-15 | 14.9 | NA | JH2 |
| 3528 | DLBCL, centroblastic | VH1 | 1-18 | 8.11 | D3-16 | JH4b |
| 3530 | DLBCL, centroblastic | VH3 | 3-07 | 24.1 | NA | JH4b |
| 2616 | DLBCL, immunoblastic | VH3 | 3-30 | 9.68 | NA | JH4b |
| 2621 | DLBCL, immunoblastic | VH3 | 3-30 | GL | D3-10 | JH6b |
| 2799 | DLBCL, immunoblastic | VH4 | 4-34 | 11.6 | D6-13 | JH4b |
| 2802 | DLBCL, immunoblastic | VH3 | LSG6.1 | 5.28 | D4-17 | JH6b |
| 2803 | DLBCL, immunoblastic | VH3 | 3-11 | 2.80 | D3-3 | JH6c |
| 2911 | DLBCL, immunoblastic | VH3 | 3-15 | 2.25 | D2-21 | JH3b |
| 3469 | DLBCL, immunoblastic | VH3 | 3-15 | 17.2 | NA | JH4b |
| 3476 | DLBCL, immunoblastic | VH4 | 4-04 | 8.62 | D4-23/D1 | JH6b |
| 3517 | DLBCL, immunoblastic | VH3 | 3-23 | 7.80 | D3-9 | JH1/JH4b |
| 3525 | DLBCL, immunoblastic | VH4 | 4-34 | 2.12 | D3-10 | JH6b |
| 2617 | BL/BLL | VH4 | 4-59 | 5.45 | D3-3 | JH6b |
| 2890 | BL/BLL | VH4 | 4-61 | 12.0 | NA | JH4b |
Case . | Histology . | IgVH family . | Closest IgVH germline gene . | % of mutation . | D . | JH . |
|---|---|---|---|---|---|---|
| 2614 | P-PTLD | VH3 | 3-74 | GL | NA | JH4b/JH5b |
| 2618 | P-PTLD | VH3 | 3-30.3 | 5.64 | D4-23 | JH6b |
| 2916 | P-PTLD | VH5 | 5-51 | 2.77 | NA | JH3b |
| 3464 | P-PTLD | VH3 | 3-15 | GL | NA | JH3b |
| 3468 | P-PTLD | VH3 | 3-07 | 12.3 | D5-18/D5-5 | JH6a |
| 3471 | P-PTLD | VH3 | 3-30 | 12.1 | D3-3 | JH6b |
| 3515 | P-PTLD | VH3 | 3-15 | 10.3 | NA | JH4b |
| 3519 | P-PTLD | VH3 | 3-30 | 10.3 | D3-22 | JH4b |
| 2798 | DLBCL, centroblastic | VH4 | 4-34 | 23.2 | NA | JH3a/JH6 |
| 2898 | DLBCL, centroblastic | VH4 | 4-34 | 11.8 | NA | JH4b |
| 2912 | DLBCL, centroblastic | VH5 | 5-51 | 4.06 | D6-19 | JH4b |
| 2914 | DLBCL, centroblastic | VH3 | 3-74 | 8.64 | D1-7 | JH4b |
| 3459 | DLBCL, centroblastic | VH1 | 1-69 | 17.6 | D3-10 | JH4d |
| 3466 | DLBCL, centroblastic | VH3 | 1-f | 3.73 | D6-19 | JH4b |
| 3467 | DLBCL, centroblastic | VH2 | S12-7 | GL | D6-25 | JH3b |
| 3518 | DLBCL, centroblastic | VH3 | 3-33 | 4.41 | D5-5/D5-18 | JH4/JH5 |
| 3522 | DLBCL, centroblastic | VH4 | 4-34 | 6.87 | D3-3 | JH3b |
| 3523 | DLBCL, centroblastic | VH1 | 1-46 | 2.71 | D4-23 | JH4b |
| 3524 | DLBCL, centroblastic | VH3 | 3-15 | 14.9 | NA | JH2 |
| 3528 | DLBCL, centroblastic | VH1 | 1-18 | 8.11 | D3-16 | JH4b |
| 3530 | DLBCL, centroblastic | VH3 | 3-07 | 24.1 | NA | JH4b |
| 2616 | DLBCL, immunoblastic | VH3 | 3-30 | 9.68 | NA | JH4b |
| 2621 | DLBCL, immunoblastic | VH3 | 3-30 | GL | D3-10 | JH6b |
| 2799 | DLBCL, immunoblastic | VH4 | 4-34 | 11.6 | D6-13 | JH4b |
| 2802 | DLBCL, immunoblastic | VH3 | LSG6.1 | 5.28 | D4-17 | JH6b |
| 2803 | DLBCL, immunoblastic | VH3 | 3-11 | 2.80 | D3-3 | JH6c |
| 2911 | DLBCL, immunoblastic | VH3 | 3-15 | 2.25 | D2-21 | JH3b |
| 3469 | DLBCL, immunoblastic | VH3 | 3-15 | 17.2 | NA | JH4b |
| 3476 | DLBCL, immunoblastic | VH4 | 4-04 | 8.62 | D4-23/D1 | JH6b |
| 3517 | DLBCL, immunoblastic | VH3 | 3-23 | 7.80 | D3-9 | JH1/JH4b |
| 3525 | DLBCL, immunoblastic | VH4 | 4-34 | 2.12 | D3-10 | JH6b |
| 2617 | BL/BLL | VH4 | 4-59 | 5.45 | D3-3 | JH6b |
| 2890 | BL/BLL | VH4 | 4-61 | 12.0 | NA | JH4b |
P-PTLD indicates polymorphic PTLD; GL, germ line; NA, not able to be aligned (the sequence between the VH and the JH gene segment could not be aligned to any known D gene); DLBCL; diffuse large B-cell lymphoma; and BL/BLL, Burkitt lymphoma/Burkitt-like lymphoma.