Table 3. Serum iron (SI), total iron... | American Society of Hematology

Table 3.

Serum iron (SI), total iron binding capacity (TIBC), and transferrin saturation (TS) by treatment in mice chronically treated with DOX

Treatment	SI, μM	TIBC, μM	TS, %
Wild-type
Saline	21.4 ± 2.9	47.6 ± 4.4	45.0 ± 6.2
DOX
Survivors	26.2 ± 4.9	47.2 ± 2.8	55.1 ± 9.7
Nonsurvivors	30.5 ± 6.8^*	33.3 ± 10.6^*	93.0 ± 9.3^*
Hfe^+/−
Saline	31.9 ± 4.3†	46.1 ± 1.8	67.0 ± 9.0†
DOX
Survivors	25.8 ± 2.9	47.8 ± 3.7	54.0 ± 8.0
Nonsurvivors	30.6 ± 6.8	33.4 ± 5.8^*	94.5 ± 18.0^*
Hfe^−/−
Saline	41.5 ± 3.7†	42.4 ± 2.1‡	98.0 ± 7.4†
DOX
Survivors	39.3 ± 8.3	41.3 ± 7.4‡	95.0 ± 7.7
Nonsurvivors	36.3 ± 10.2	36.6 ± 10.0	99.5 ± 8.1

Treatment	SI, μM	TIBC, μM	TS, %
Wild-type
Saline	21.4 ± 2.9	47.6 ± 4.4	45.0 ± 6.2
DOX
Survivors	26.2 ± 4.9	47.2 ± 2.8	55.1 ± 9.7
Nonsurvivors	30.5 ± 6.8^*	33.3 ± 10.6^*	93.0 ± 9.3^*
Hfe^+/−
Saline	31.9 ± 4.3†	46.1 ± 1.8	67.0 ± 9.0†
DOX
Survivors	25.8 ± 2.9	47.8 ± 3.7	54.0 ± 8.0
Nonsurvivors	30.6 ± 6.8	33.4 ± 5.8^*	94.5 ± 18.0^*
Hfe^−/−
Saline	41.5 ± 3.7†	42.4 ± 2.1‡	98.0 ± 7.4†
DOX
Survivors	39.3 ± 8.3	41.3 ± 7.4‡	95.0 ± 7.7
Nonsurvivors	36.3 ± 10.2	36.6 ± 10.0	99.5 ± 8.1

Data are presented as means ± SD.

P < .001, comparison between saline-treated and DOX-treated mice.

P < .0001, comparison between wild-type and mutant mice with the same treatment.

P < .05, comparison between wild-type and mutant mice with the same treatment.