Summary of vector injections in hemophilia B dogs
Animal . | Vector . | Total no. transducing units/kg body weight . | Total no. vp/kg body weight . | Serum concentrations of cFIX 3 d after injection, ng/mL . |
|---|---|---|---|---|
| Hemophilia B dog G11 | AdFTC/cFIX/ChMAR | 4.3 × 1010 | 8.57 × 1011 | 2214 |
| Hemophilia B dog G21 | AdFTC/cFIX/ChMAR | 2.95 × 1010 | 6.0 × 1011 | 534 |
Animal . | Vector . | Total no. transducing units/kg body weight . | Total no. vp/kg body weight . | Serum concentrations of cFIX 3 d after injection, ng/mL . |
|---|---|---|---|---|
| Hemophilia B dog G11 | AdFTC/cFIX/ChMAR | 4.3 × 1010 | 8.57 × 1011 | 2214 |
| Hemophilia B dog G21 | AdFTC/cFIX/ChMAR | 2.95 × 1010 | 6.0 × 1011 | 534 |
The total amount of transducing units per kilogram body weight and viral particles per kilogram body weight per injected animal are shown. The total number of transducing units was determined by a quantitative Southern blot as described in “Materials and methods.” The serum concentration of the cFIX was determined by ELISA.