Baseline characteristics of study and reference patients with FL undergoing high-dose therapy and ASCT
. | HD-RIT, n = 27 . | . | C-HDT, n = 98 . | . | . | ||
---|---|---|---|---|---|---|---|
Characteristic . | No. . | % . | No. . | % . | P . | ||
Bulk at Tx | |||||||
Less than 5 cm | 19 | 70 | 77 | 79 | .1 | ||
5 cm or more | 8 | 30 | 14 | 14 | |||
Unknown | 0 | 0 | 7 | 7 | |||
Male sex | 15 | 56 | 61 | 62 | .53 | ||
Median age, y (range) | 46 (24-59) | 49 (30-59) | .06 | ||||
Stages III/IV at Tx | 26 | 96 | 89 | 91 | .35 | ||
LDH at Tx | |||||||
Elevated | 11 | 41 | 17 | 17 | .03 | ||
Normal | 16 | 59 | 69 | 70 | |||
Unknown | 0 | 12 | 12 | ||||
Age-adjusted IPI score | |||||||
0 | 1 | 4 | 8 | 8 | |||
1 | 15 | 56 | 62 | 63 | .019 | ||
2 | 11 | 41 | 16 | 16 | (0-1 vs 2-3) | ||
3 | 0 | 0 | 0 | 0 | |||
Unknown | 12 | 12 | |||||
Transformed to DLBCL | 4 | 15 | 8 | 8 | .3 | ||
Documented splenomegaly | 7 | 26 | 14 | 14 | .15 | ||
Median no. prior regimens | 2(1-6) | 2(1-11) | |||||
mean = 2.85 | mean = 2.32 | ||||||
3 or more prior regimens | 13 | 48 | 33 | 34 | .17 | ||
Prior anthracycline | 20 | 74 | 86 | 87 | .08 | ||
Prior platinum | 10 | 37 | 34 | 35 | .82 | ||
Prior radiation | 2 | 7 | 19 | 19 | .24 | ||
Chemosensitive disease | 16 | 59 | 66 | 67 | .57 | ||
Chemoresistant/primary refractory at Tx | 2 | 7 | 13 | 13 | |||
Untreated relapse at Tx | 9 | 33 | 19 | 19 |
. | HD-RIT, n = 27 . | . | C-HDT, n = 98 . | . | . | ||
---|---|---|---|---|---|---|---|
Characteristic . | No. . | % . | No. . | % . | P . | ||
Bulk at Tx | |||||||
Less than 5 cm | 19 | 70 | 77 | 79 | .1 | ||
5 cm or more | 8 | 30 | 14 | 14 | |||
Unknown | 0 | 0 | 7 | 7 | |||
Male sex | 15 | 56 | 61 | 62 | .53 | ||
Median age, y (range) | 46 (24-59) | 49 (30-59) | .06 | ||||
Stages III/IV at Tx | 26 | 96 | 89 | 91 | .35 | ||
LDH at Tx | |||||||
Elevated | 11 | 41 | 17 | 17 | .03 | ||
Normal | 16 | 59 | 69 | 70 | |||
Unknown | 0 | 12 | 12 | ||||
Age-adjusted IPI score | |||||||
0 | 1 | 4 | 8 | 8 | |||
1 | 15 | 56 | 62 | 63 | .019 | ||
2 | 11 | 41 | 16 | 16 | (0-1 vs 2-3) | ||
3 | 0 | 0 | 0 | 0 | |||
Unknown | 12 | 12 | |||||
Transformed to DLBCL | 4 | 15 | 8 | 8 | .3 | ||
Documented splenomegaly | 7 | 26 | 14 | 14 | .15 | ||
Median no. prior regimens | 2(1-6) | 2(1-11) | |||||
mean = 2.85 | mean = 2.32 | ||||||
3 or more prior regimens | 13 | 48 | 33 | 34 | .17 | ||
Prior anthracycline | 20 | 74 | 86 | 87 | .08 | ||
Prior platinum | 10 | 37 | 34 | 35 | .82 | ||
Prior radiation | 2 | 7 | 19 | 19 | .24 | ||
Chemosensitive disease | 16 | 59 | 66 | 67 | .57 | ||
Chemoresistant/primary refractory at Tx | 2 | 7 | 13 | 13 | |||
Untreated relapse at Tx | 9 | 33 | 19 | 19 |
Tx indicates transplantation; DLBCL, diffuse large B-cell lymphoma.