Table 3. Genes induced by TCR agonists... | American Society of Hematology

Table 3.

Genes induced by TCR agonists in neutrophils

	MIP-1α			MIP-1β			MIP-3α	GRO-α			IL-1β			IL-8
Untreated
Alone	0.002	(100)	0.008	(100)	0.000	0.016	(100)	0.033	(100)	0.318	(100)
Plus GM-CSF	0.001	(0.6)	0.002	(0.3)	0.000	0.032	(2.0)	0.281	(8.5)	0.490	(1.5)
LPS
Alone	0.110	(50.0)	0.376	(50.0)	0.017	0.090	(5.6)	1.000	(30.3)	2.568	(8.1)
Plus GM-CSF	0.030	(13.4)	0.406	(53.9)	0.011	0.099	(6.1)	1.506	(45.7)	3.119	(9.8)
Lipopeptide
Alone	0.050	(22.7)	0.114	(15.2)	0.033	0.068	(4.2)	2.380	(72.2)	5.986	(18.8)
Plus GM-CSF	0.026	(11.7)	0.285	(37.9)	0.020	0.074	(4.6)	2.220	(67.3)	7.021	(22.0)
Poly I:C
Alone	0.004	(1.9)	0.008	(1.0)	0.000	0.013	(0.8)	0.031	(1.0)	0.562	(1.8)
Plus GM-CSF	0.002	(0.9)	0.003	(0.4)	0.000	0.041	(2.6)	0.351	(10.7)	0.510	(1.6)
Flagellin
Alone	0.045	(20.6)	0.104	(13.9)	0.020	0.053	(3.3)	0.323	(9.8)	1.516	(4.8)
Plus GM-CSF	0.015	(7.0)	0.197	(26.2)	0.000	0.075	(4.7)	1.816	(55.1)	4.283	(13.5)
CpG DNA
Alone	0.001	(0.6)	0.009	(1.1)	0.000	0.022	(1.4)	0.089	(2.7)	0.180	(0.6)
Plus GM-CSF	0.002	(1.1)	0.138	(18.3)	0.008	0.076	(4.7)	0.834	(25.3)	3.144	(9.9)
Zymosan
Alone	0.088	(40.0)	0.171	(22.7)	0.012	0.069	(4.3)	0.514	(15.6)	4.696	(14.7)
Plus GM-CSF	0.072	(32.8)	0.268	(35.6)	0.020	0.121	(7.6)	1.366	(41.4)	4.381	(13.8)
R848
Alone	0.210	(95.3)	0.299	(39.8)	0.015	0.072	(4.5)	0.889	(27.0)	1.987	(6.2)
Plus GM-CSF	0.305	(138.5)	0.525	(69.7)	0.023	0.096	(6.0)	2.130	(64.6)	6.735	(21.1)

	MIP-1α			MIP-1β			MIP-3α	GRO-α			IL-1β			IL-8
Untreated
Alone	0.002	(100)	0.008	(100)	0.000	0.016	(100)	0.033	(100)	0.318	(100)
Plus GM-CSF	0.001	(0.6)	0.002	(0.3)	0.000	0.032	(2.0)	0.281	(8.5)	0.490	(1.5)
LPS
Alone	0.110	(50.0)	0.376	(50.0)	0.017	0.090	(5.6)	1.000	(30.3)	2.568	(8.1)
Plus GM-CSF	0.030	(13.4)	0.406	(53.9)	0.011	0.099	(6.1)	1.506	(45.7)	3.119	(9.8)
Lipopeptide
Alone	0.050	(22.7)	0.114	(15.2)	0.033	0.068	(4.2)	2.380	(72.2)	5.986	(18.8)
Plus GM-CSF	0.026	(11.7)	0.285	(37.9)	0.020	0.074	(4.6)	2.220	(67.3)	7.021	(22.0)
Poly I:C
Alone	0.004	(1.9)	0.008	(1.0)	0.000	0.013	(0.8)	0.031	(1.0)	0.562	(1.8)
Plus GM-CSF	0.002	(0.9)	0.003	(0.4)	0.000	0.041	(2.6)	0.351	(10.7)	0.510	(1.6)
Flagellin
Alone	0.045	(20.6)	0.104	(13.9)	0.020	0.053	(3.3)	0.323	(9.8)	1.516	(4.8)
Plus GM-CSF	0.015	(7.0)	0.197	(26.2)	0.000	0.075	(4.7)	1.816	(55.1)	4.283	(13.5)
CpG DNA
Alone	0.001	(0.6)	0.009	(1.1)	0.000	0.022	(1.4)	0.089	(2.7)	0.180	(0.6)
Plus GM-CSF	0.002	(1.1)	0.138	(18.3)	0.008	0.076	(4.7)	0.834	(25.3)	3.144	(9.9)
Zymosan
Alone	0.088	(40.0)	0.171	(22.7)	0.012	0.069	(4.3)	0.514	(15.6)	4.696	(14.7)
Plus GM-CSF	0.072	(32.8)	0.268	(35.6)	0.020	0.121	(7.6)	1.366	(41.4)	4.381	(13.8)
R848
Alone	0.210	(95.3)	0.299	(39.8)	0.015	0.072	(4.5)	0.889	(27.0)	1.987	(6.2)
Plus GM-CSF	0.305	(138.5)	0.525	(69.7)	0.023	0.096	(6.0)	2.130	(64.6)	6.735	(21.1)

Data are presented as copies of mRNA over copies of β₂-microglobulin. Parentheses indicate fold induction over untreated.