Multivariate analysis of overall survival
Variables . | Relative risk of death (95% CI) . | P . |
|---|---|---|
| Type of transplant* | < .001§ | |
| Autologous unpurged, n = 597 | 1.00 | — |
| Autologous purged, n = 131 | 0.67 (0.48-0.95) | .03 |
| Allogeneic, n = 176† | — | |
| First 6 mo after transplantation | 3.59 (2.52-5.10) | < .001 |
| 6 mo after transplantation | 0.71 (0.44-1.13) | .14 |
| Disease stage at transplantation‡ | — | |
| Early, n = 504 | 1.00 | — |
| Advanced, n = 400 | 1.26 (1.01-1.57) | .04 |
| Chemosensitivity | < .001∥ | |
| Sensitive, n = 717 | 1.00 | — |
| Resistant, n = 111 | 2.63 (2.01-3.44) | < .001 |
| Untreated/unknown, n = 76 | 1.42 (1.00-2.02) | .06 |
| Serum LDH at transplantation | < .001∥ | |
| Normal, n = 561 | 1.00 | — |
| Abnormal, n = 245 | 2.26 (1.79-2.84) | < .001 |
| Unknown, n = 98 | 2.11 (1.48-3.01) | < .001 |
| Karnofsky performance score at transplantation | — | |
| 90%-100%, n = 644 | 1.00 | — |
| No more than 80%, n = 260 | 1.51 (1.21-1.88) | < .001 |
| Interval from diagnosis to transplantation | .001∥ | |
| Less than 1 y, n = 168 | 1.00 | — |
| 1-2 y, n = 244 | 1.71 (1.20-2.42) | .003 |
| More than 2 y, n = 492 | 1.38 (1.01-1.90) | .05 |
| Age at transplantation | — | |
| No older than 40 y, n = 199 | 1.00 | — |
| Older than 40 y, n = 705 | 1.42 (1.07-1.88) | .01 |
| Year of transplantation | .007∥ | |
| 1990-1993, n = 301 | 1.00 | — |
| 1994-1996, n = 374 | 0.71 (0.55-0.90) | .006 |
| 1997-1998, n = 229 | 0.67 (0.49-0.2) | .01 |
Variables . | Relative risk of death (95% CI) . | P . |
|---|---|---|
| Type of transplant* | < .001§ | |
| Autologous unpurged, n = 597 | 1.00 | — |
| Autologous purged, n = 131 | 0.67 (0.48-0.95) | .03 |
| Allogeneic, n = 176† | — | |
| First 6 mo after transplantation | 3.59 (2.52-5.10) | < .001 |
| 6 mo after transplantation | 0.71 (0.44-1.13) | .14 |
| Disease stage at transplantation‡ | — | |
| Early, n = 504 | 1.00 | — |
| Advanced, n = 400 | 1.26 (1.01-1.57) | .04 |
| Chemosensitivity | < .001∥ | |
| Sensitive, n = 717 | 1.00 | — |
| Resistant, n = 111 | 2.63 (2.01-3.44) | < .001 |
| Untreated/unknown, n = 76 | 1.42 (1.00-2.02) | .06 |
| Serum LDH at transplantation | < .001∥ | |
| Normal, n = 561 | 1.00 | — |
| Abnormal, n = 245 | 2.26 (1.79-2.84) | < .001 |
| Unknown, n = 98 | 2.11 (1.48-3.01) | < .001 |
| Karnofsky performance score at transplantation | — | |
| 90%-100%, n = 644 | 1.00 | — |
| No more than 80%, n = 260 | 1.51 (1.21-1.88) | < .001 |
| Interval from diagnosis to transplantation | .001∥ | |
| Less than 1 y, n = 168 | 1.00 | — |
| 1-2 y, n = 244 | 1.71 (1.20-2.42) | .003 |
| More than 2 y, n = 492 | 1.38 (1.01-1.90) | .05 |
| Age at transplantation | — | |
| No older than 40 y, n = 199 | 1.00 | — |
| Older than 40 y, n = 705 | 1.42 (1.07-1.88) | .01 |
| Year of transplantation | .007∥ | |
| 1990-1993, n = 301 | 1.00 | — |
| 1994-1996, n = 374 | 0.71 (0.55-0.90) | .006 |
| 1997-1998, n = 229 | 0.67 (0.49-0.2) | .01 |
— indicates reference group; LDH, lactate dehydrogenase.
Time-dependent covariate; such that risk of death before and after 6 months after transplantation varies.
Allogeneic (≤ 6 months) versus autologous-purged transplantation (RR, 5.33; 95% CI, 3.34-8.50; P < .001); allogeneic (> 6 months) versus autologous-purged transplantation (RR, 1.05; 95% CI, 0.60-1.83; P < .87).
Early disease indicates complete remission (1st or 2nd) or relapse (1st); advanced disease, complete remission (3rd) or relapse (> 2nd) or primary induction failure.
Determined by 3-degree of freedom test.
Determined by 2-degree of freedom test.