Multivariate analysis of disease-free-survival
Variables . | Relative risk of treatment failure (95% CI) . | P . |
|---|---|---|
| Type of transplant* | < .001§ | |
| Autologous unpurged, n = 596 | 1.00 | — |
| Autologous purged, n = 130 | 0.82 (0.63-1.07) | .14 |
| Allogeneic, n = 175† | — | |
| First 6 mo after transplantation | 1.77 (1.34-2.34) | < .001 |
| 6 mo after transplantation | 0.35 (0.22-0.57) | < .001 |
| Disease stage at transplantation‡ | — | |
| Early (n = 501) | 1.00 | — |
| Advanced (n = 400) | 1.27 (1.07-1.52) | .007 |
| Chemosensitivity | < .001∥ | |
| Sensitive, n = 714 | 1.00 | — |
| Resistant, n = 111 | 1.92 (1.52-2.44) | < .001 |
| Untreated/unknown, n = 76 | 1.12 (0.83-1.53) | .45 |
| Serum LDH at transplantation | < .001∥ | |
| Normal, n = 561 | 1.00 | — |
| Abnormal, n = 243 | 1.58 (1.30-1.93) | < .0001 |
| Unknown, n = 97 | 0.95 (0.70-1.30) | .76 |
| Karnofsky performance score at transplantation | — | |
| 90%-100%, n = 641 | 1.00 | — |
| No more than 80%, n = 260 | 1.31 (1.09-1.57) | .004 |
| Interval from diagnosis to transplantation | .05∥ | |
| Less than 1 y, n = 168 | 1.00 | — |
| 1-2 y, n = 244 | 1.37 (1.04-1.80) | .03 |
| More than 2 y, n = 489 | 1.35 (1.06-1.72) | .02 |
| Age at transplantation | — | |
| No older than 40 y, n = 198 | 1.00 | — |
| Older than 40 y, n = 703 | 1.31 (1.04-1.64) | .02 |
Variables . | Relative risk of treatment failure (95% CI) . | P . |
|---|---|---|
| Type of transplant* | < .001§ | |
| Autologous unpurged, n = 596 | 1.00 | — |
| Autologous purged, n = 130 | 0.82 (0.63-1.07) | .14 |
| Allogeneic, n = 175† | — | |
| First 6 mo after transplantation | 1.77 (1.34-2.34) | < .001 |
| 6 mo after transplantation | 0.35 (0.22-0.57) | < .001 |
| Disease stage at transplantation‡ | — | |
| Early (n = 501) | 1.00 | — |
| Advanced (n = 400) | 1.27 (1.07-1.52) | .007 |
| Chemosensitivity | < .001∥ | |
| Sensitive, n = 714 | 1.00 | — |
| Resistant, n = 111 | 1.92 (1.52-2.44) | < .001 |
| Untreated/unknown, n = 76 | 1.12 (0.83-1.53) | .45 |
| Serum LDH at transplantation | < .001∥ | |
| Normal, n = 561 | 1.00 | — |
| Abnormal, n = 243 | 1.58 (1.30-1.93) | < .0001 |
| Unknown, n = 97 | 0.95 (0.70-1.30) | .76 |
| Karnofsky performance score at transplantation | — | |
| 90%-100%, n = 641 | 1.00 | — |
| No more than 80%, n = 260 | 1.31 (1.09-1.57) | .004 |
| Interval from diagnosis to transplantation | .05∥ | |
| Less than 1 y, n = 168 | 1.00 | — |
| 1-2 y, n = 244 | 1.37 (1.04-1.80) | .03 |
| More than 2 y, n = 489 | 1.35 (1.06-1.72) | .02 |
| Age at transplantation | — | |
| No older than 40 y, n = 198 | 1.00 | — |
| Older than 40 y, n = 703 | 1.31 (1.04-1.64) | .02 |
— indicates reference group; LDH, lactate dehydrogenase.
Time-dependent covariate; such that risk of death before and after 6 months after transplantation varies.
Allogeneic (≤ 6 months) versus autologous-purged transplantation (RR, 2.15; 95% CI, 1.50-3.08; P < .001); allogeneic (> 6 months) versus autologous-purged transplantation (RR, 0.43; 95% CI, 0.26-0.73; P < .001).
Early disease indicates complete remission (1st or 2nd) or relapse (1st); advanced disease, complete remission (3rd) or relapse (> 2nd) or primary induction failure.
Determined by 3-degree of freedom test.
Determined by 2-degree of freedom test.