Multivariate analysis of relapse
Variables . | Relative risk of relapse (95% CI) . | P . |
|---|---|---|
| Type of transplant* | < .001‡ | |
| Autologous unpurged, n = 596 | 1.00 | — |
| Autologous purged, n = 130 | 0.74 (0.55-0.99) | .04 |
| Allogeneic, n = 175 | 0.46 (0.33-0.66) | < .001 |
| Disease stage at transplantation† | — | |
| Early, n = 501 | 1.00 | — |
| Advanced, n = 400 | 1.29 (1.06-1.58) | .01 |
| Chemosensitivity | .001‡ | |
| Sensitive, n = 714 | 1.00 | — |
| Resistant, n = 111 | 1.69 (1.27-2.23) | < .001 |
| Untreated/unknown, n = 76 | 0.98 (0.68-1.42) | .93 |
| Serum LDH at transplantation | < .001‡ | |
| Normal, n = 561 | 1.00 | — |
| Abnormal, n = 243 | 1.51 (1.21-1.87) | < .001 |
| Unknown, n = 97 | 1.00 (0.69-1.43) | .98 |
| Karnofsky performance score at transplantation | — | |
| 90%-100%, n = 641 | 1.00 | — |
| No more than 80%, n = 260 | 1.31 (1.07-1.61) | .01 |
| Conditioning regimen | — | |
| Non-TBI, n = 553 | 1.00 | — |
| TBI, n = 348 | 0.77 (0.62-0.95) | .02 |
| Interval from diagnosis to transplantation | .05‡ | |
| Less than 1 y, n = 168 | 1.00 | — |
| 1-2 y, n = 244 | 1.37 (1.01-1.87) | .05 |
| More than 2 y, n = 489 | 1.40 (1.06-1.84) | .01 |
| Bone marrow involvement at transplantation | — | |
| No, n = 705 | 1.00 | — |
| Yes, n = 196 | 1.31 (1.04-1.65) | .02 |
Variables . | Relative risk of relapse (95% CI) . | P . |
|---|---|---|
| Type of transplant* | < .001‡ | |
| Autologous unpurged, n = 596 | 1.00 | — |
| Autologous purged, n = 130 | 0.74 (0.55-0.99) | .04 |
| Allogeneic, n = 175 | 0.46 (0.33-0.66) | < .001 |
| Disease stage at transplantation† | — | |
| Early, n = 501 | 1.00 | — |
| Advanced, n = 400 | 1.29 (1.06-1.58) | .01 |
| Chemosensitivity | .001‡ | |
| Sensitive, n = 714 | 1.00 | — |
| Resistant, n = 111 | 1.69 (1.27-2.23) | < .001 |
| Untreated/unknown, n = 76 | 0.98 (0.68-1.42) | .93 |
| Serum LDH at transplantation | < .001‡ | |
| Normal, n = 561 | 1.00 | — |
| Abnormal, n = 243 | 1.51 (1.21-1.87) | < .001 |
| Unknown, n = 97 | 1.00 (0.69-1.43) | .98 |
| Karnofsky performance score at transplantation | — | |
| 90%-100%, n = 641 | 1.00 | — |
| No more than 80%, n = 260 | 1.31 (1.07-1.61) | .01 |
| Conditioning regimen | — | |
| Non-TBI, n = 553 | 1.00 | — |
| TBI, n = 348 | 0.77 (0.62-0.95) | .02 |
| Interval from diagnosis to transplantation | .05‡ | |
| Less than 1 y, n = 168 | 1.00 | — |
| 1-2 y, n = 244 | 1.37 (1.01-1.87) | .05 |
| More than 2 y, n = 489 | 1.40 (1.06-1.84) | .01 |
| Bone marrow involvement at transplantation | — | |
| No, n = 705 | 1.00 | — |
| Yes, n = 196 | 1.31 (1.04-1.65) | .02 |
— indicates reference group; LDH, lactate dehydrogenase; and TBI, total body irradiation.
Allogeneic versus autologous purged transplantation (RR, 0.63; 95% CI, 0.41-0.97; P < .03).
Early disease indicates complete remission (1st or 2nd) or relapse (1st); advanced disease, complete remission (3rd) or relapse (> 2nd) or primary induction failure.
Determined by 2-degree of freedom test.