Table 1. In vitro characterization of... | American Society of Hematology

Table 1.

In vitro characterization of AAV-cFVIII vectors

Vector lot	Genome titer, vg/mL	Capsid titer, cp/mL	Ratio of total to full capsids	Transduced HepG2, vg/well	In vitro activity, mU/mL	Dog injected
17-26	2.7 × 10¹²	3.6 × 10¹³	13	1 × 10⁶	260	Elisa
510-1	4.5 × 10¹²	4.3 × 10¹³	10	1 × 10⁶	275	Junior

Vector lot	Genome titer, vg/mL	Capsid titer, cp/mL	Ratio of total to full capsids	Transduced HepG2, vg/well	In vitro activity, mU/mL	Dog injected
17-26	2.7 × 10¹²	3.6 × 10¹³	13	1 × 10⁶	260	Elisa
510-1	4.5 × 10¹²	4.3 × 10¹³	10	1 × 10⁶	275	Junior

Ratio of total to full capsids is equivalent to the ratio of the capsid titer to genome titer.

vg/mL indicates vector genomes/mL; and cp/mL, capsid (empty and fulls) particles/mL.