Table 1. In vitro effect of imatinib... | American Society of Hematology

Table 1.

In vitro effect of imatinib mesylate on autonomous BFU-E growth in PV patients

		Autonomous BFU-Es ± SD per dish*
Patient	Source	Control	Imatinib mesylate, 10 μM	Percent inhibition	P
A	PB	126 ± 24.6	48 ± 5.6	62	.008
B	PB	2 ± 0.6	0 ± 0	100	.007
C	BM	19 ± 8	0 ± 0	100	.015
D	PB	8 ± 1.5	0 ± 0	100	.001
E	PB	8 ± 3	0 ± 0	100	.009
F	PB	31 ± 8	2 ± 1	94	.004
G	PB	54 ± 6.1	5 ± 1	91	<.001
H	PB	7 ± 2	0 ± 0.3	100	.005
I	PB	4 ± 2.5	0 ± 0	100	.041
J	PB	9 ± 0.6	0 ± 0	100	<.001
K	PB	4 ± 1.1	0 ± 0.3	100	.038
L	PB	21 ± 2	1 ± 0.5	95	<.001
M	PB	103 ± 13	9 ± 3	91	<.001

		Autonomous BFU-Es ± SD per dish*
Patient	Source	Control	Imatinib mesylate, 10 μM	Percent inhibition	P
A	PB	126 ± 24.6	48 ± 5.6	62	.008
B	PB	2 ± 0.6	0 ± 0	100	.007
C	BM	19 ± 8	0 ± 0	100	.015
D	PB	8 ± 1.5	0 ± 0	100	.001
E	PB	8 ± 3	0 ± 0	100	.009
F	PB	31 ± 8	2 ± 1	94	.004
G	PB	54 ± 6.1	5 ± 1	91	<.001
H	PB	7 ± 2	0 ± 0.3	100	.005
I	PB	4 ± 2.5	0 ± 0	100	.041
J	PB	9 ± 0.6	0 ± 0	100	<.001
K	PB	4 ± 1.1	0 ± 0.3	100	.038
L	PB	21 ± 2	1 ± 0.5	95	<.001
M	PB	103 ± 13	9 ± 3	91	<.001

BFU-E indicates erythroid burst-forming unit; PV, polycythemia vera; SD, standard deviation; PB, peripheral blood; BM, bone marrow.

Mean number of erythroid bursts per 10⁵ mononuclear cells ± SD from triplicates.