Hemodynamic characteristics of BM microvessels
. | Nonirradiated . | Irradiated . | P . |
|---|---|---|---|
| Vessel diameter (μm) | 42.3 ± 2 | 45.7 ± 4 | .39 |
| V max (μm/s) | 1788.5 ± 193 | 1771.8 ± 181 | .95 |
| WSR (s-1) | 212.7 ± 29 | 191.8 ± 23 | .60 |
. | Nonirradiated . | Irradiated . | P . |
|---|---|---|---|
| Vessel diameter (μm) | 42.3 ± 2 | 45.7 ± 4 | .39 |
| V max (μm/s) | 1788.5 ± 193 | 1771.8 ± 181 | .95 |
| WSR (s-1) | 212.7 ± 29 | 191.8 ± 23 | .60 |
The velocity of free-flowing cells was determined in BM microvessels of irradiated (3 hours after a single 12 Gy dose) or nonirradiated mice after the injection of fluorescently labeled mononuclear and red blood cells obtained from the BM of donor mice. Vessel diameters were measured using a video caliper, and mean blood velocity (Vmax) and wall shear rates (WSRs) were calculated as described.22 Data shown are means ± SEMs from 32 (nonirradiated) and 21 (irradiated) vessels. P values given compare the different parameters between irradiated and nonirradiated groups.