Table 1. Cytolytic properties and... | American Society of Hematology

Table 1.

Cytolytic properties and replicative history of peripheral blood pE CD8⁺ T lymphocytes

	N RA⁺CCR7⁺ 27⁺28⁺	pE₁ RA⁺CCR7^- 27⁺28⁺	pE₂ RA⁺CCR7^- 27⁺28^-	E RA⁺CCR7^- 27^-28^-
Fas/CD95*, %	5	78	66‡	72
Granzyme B*, %	1	25	49‡	93
Perforin*, %	0	23	41‡	95
Cytolysis ⁵¹Cr, %	< 3§	12	12	100
IFN-γ/TNF-α	-	+	+	+
NKR/CD94	-	+/-	++	+++
TRECs†	13	2	1.5	ND
Telomere length, kb	7	10	10	5.5

	N RA⁺CCR7⁺ 27⁺28⁺	pE₁ RA⁺CCR7^- 27⁺28⁺	pE₂ RA⁺CCR7^- 27⁺28^-	E RA⁺CCR7^- 27^-28^-
Fas/CD95*, %	5	78	66‡	72
Granzyme B*, %	1	25	49‡	93
Perforin*, %	0	23	41‡	95
Cytolysis ⁵¹Cr, %	< 3§	12	12	100
IFN-γ/TNF-α	-	+	+	+
NKR/CD94	-	+/-	++	+++
TRECs†	13	2	1.5	ND
Telomere length, kb	7	10	10	5.5

NKR indicates NK cell receptor; ND, not detectable; and kb, kilobase.

Percentage of positive cells by FACS analysis (mean percent of analysis performed in 5 healthy individuals).

Mean numbers of TRECs per 100 cells from 4 healthy individuals (Figure 6A).

Expression of Fas, granzyme B, and perforin in pE₂ T cells was calculated based on the proportion of pE₂ T cells in the total pE population.

Comparison of the lytic activity found in N, pE₁, and pE₂ subsets with that found in the E subset (Figure 4C).