Molecular features of 13 paired diagnosis-transformation samples
. | BCL6 partner . | . | BCL2 breakpoint* . | . | ||
|---|---|---|---|---|---|---|
| Case . | At diagnosis . | At transformation . | At diagnosis . | At transformation . | ||
| IL105 | A deletion | A deletion | A 5′mcr | A 5′mcr | ||
| IL114 | A MBNL | G | A mcr | A mcr | ||
| IL115 | G | G | A Far 3′-MBR | A Far 3′-MBR | ||
| IL116 | A similar to NAPA | A similar to NAPA | A 150-bp MBR | A 150-bp MBR | ||
| IL117 | G | G | A 150-bp MBR | A 150-bp MBR | ||
| IL119 | A GRHPR, 6q16.1 | A GRHPR, 6q16.1 | A mcr | A mcr | ||
| IL120 | G | G | A 150-bp MBR | A 150-bp MBR | ||
| IL121 | G | G | A Far 3′-MBR | A Far 3′-MBR | ||
| IL122 | A 3q28 | A 3q28, IGH | A 150-bp MBR | A 150-bp MBR | ||
| IL123 | G | G | A mcr | A mcr | ||
| IL124 | A CIITA | A CIITA | A 3′-MBR | A 3′-MBR | ||
| IL125 | A U50HG | G | ND | ND | ||
| IL126 | A EIF4A2, LRMP | A EIF4A2 | ND | ND | ||
. | BCL6 partner . | . | BCL2 breakpoint* . | . | ||
|---|---|---|---|---|---|---|
| Case . | At diagnosis . | At transformation . | At diagnosis . | At transformation . | ||
| IL105 | A deletion | A deletion | A 5′mcr | A 5′mcr | ||
| IL114 | A MBNL | G | A mcr | A mcr | ||
| IL115 | G | G | A Far 3′-MBR | A Far 3′-MBR | ||
| IL116 | A similar to NAPA | A similar to NAPA | A 150-bp MBR | A 150-bp MBR | ||
| IL117 | G | G | A 150-bp MBR | A 150-bp MBR | ||
| IL119 | A GRHPR, 6q16.1 | A GRHPR, 6q16.1 | A mcr | A mcr | ||
| IL120 | G | G | A 150-bp MBR | A 150-bp MBR | ||
| IL121 | G | G | A Far 3′-MBR | A Far 3′-MBR | ||
| IL122 | A 3q28 | A 3q28, IGH | A 150-bp MBR | A 150-bp MBR | ||
| IL123 | G | G | A mcr | A mcr | ||
| IL124 | A CIITA | A CIITA | A 3′-MBR | A 3′-MBR | ||
| IL125 | A U50HG | G | ND | ND | ||
| IL126 | A EIF4A2, LRMP | A EIF4A2 | ND | ND | ||
A indicates nongermline-altered PCR amplification; G, germline-derived PCR amplification; bp, base pair; and ND, not detected.
The classification of BCL2 breakpoint was described previously.52