Comparison of BCL6 translocation in FL
. | Our study . | . | . | . | . | |
|---|---|---|---|---|---|---|
. | Transformation . | Not known to transform . | US 1994 (Lo Coco et al34 ) . | France 1994 (Bastard et al27 ) . | US 1995 (Otsuki et al11 ) . | |
| BCL6 translocation* | 16/41† | 9/64† | 2/31 | 11/80 | 6/42 | |
| Ratio (%) | 39.0 | 14.1 | 6.4 | 13.8 | 14.3 | |
| P value | .0048‡ | .0020‡ | .0025‡ | .0134‡ | ||
| Methodology | LDI-PCR | LDI-PCR | Southern blot (Sac 4.0§) | Southern blot (F372§) | Southern blot (F372§) | |
. | Our study . | . | . | . | . | |
|---|---|---|---|---|---|---|
. | Transformation . | Not known to transform . | US 1994 (Lo Coco et al34 ) . | France 1994 (Bastard et al27 ) . | US 1995 (Otsuki et al11 ) . | |
| BCL6 translocation* | 16/41† | 9/64† | 2/31 | 11/80 | 6/42 | |
| Ratio (%) | 39.0 | 14.1 | 6.4 | 13.8 | 14.3 | |
| P value | .0048‡ | .0020‡ | .0025‡ | .0134‡ | ||
| Methodology | LDI-PCR | LDI-PCR | Southern blot (Sac 4.0§) | Southern blot (F372§) | Southern blot (F372§) | |
BCL6 translocation means nongermline-altered PCR amplification by LDI-PCR or rearrangement by Southern blot.
Two cases, which had a point mutation leading to the generation of a restriction site, were excluded from positive cases.
P value of transformation cases versus cases not known to transform, US 1994, France 1994, and US 1995, respectively.
Sac 4.0 or F372 was used to detect BCL6 rearrangement as a probe for Southern blot (Figure 2).