DFS analysis for the comparison of donor versus no donor according to the cytogenetic groups and 3 possible grouping systems
. | No donor, n . | Donor, n . | Estimated HR . | 95% CI . |
|---|---|---|---|---|
| EORTC/GIMEMA | ||||
| Favorable* | 73 | 50 | 1.21 | 0.66, 2.25 |
| NN, -Y only | 104 | 61 | 1.16 | 0.75, 1.81 |
| Others (bad)* | 56 | 22 | 0.33 | 0.15, 0.75 |
| Very bad* | 38 | 42 | 0.65 | 0.39, 1.10 |
| SWOG/ECOG | ||||
| Favorable† | 67 | 46 | 1.27 | 0.67, 2.42 |
| Intermediate‡ | 116 | 67 | 1.02 | 0.67, 1.55 |
| Others | 36 | 9 | 0.27 | 0.07, 1.16 |
| Unfavorable§ | 52 | 53 | 0.64 | 0.40, 1.02 |
| MRC | ||||
| Favorable* | 73 | 50 | 1.21 | 0.66, 2.25 |
| NN, -Y only | 104 | 61 | 1.16 | 0.75, 1.81 |
| Others | 81 | 47 | 0.55 | 0.64, 0.88 |
| Intermediate∥ | 0.83 | 0.60, 1.14 | ||
| Adverse¶ | 13 | 17 | 0.59 | 0.26, 1.36 |
. | No donor, n . | Donor, n . | Estimated HR . | 95% CI . |
|---|---|---|---|---|
| EORTC/GIMEMA | ||||
| Favorable* | 73 | 50 | 1.21 | 0.66, 2.25 |
| NN, -Y only | 104 | 61 | 1.16 | 0.75, 1.81 |
| Others (bad)* | 56 | 22 | 0.33 | 0.15, 0.75 |
| Very bad* | 38 | 42 | 0.65 | 0.39, 1.10 |
| SWOG/ECOG | ||||
| Favorable† | 67 | 46 | 1.27 | 0.67, 2.42 |
| Intermediate‡ | 116 | 67 | 1.02 | 0.67, 1.55 |
| Others | 36 | 9 | 0.27 | 0.07, 1.16 |
| Unfavorable§ | 52 | 53 | 0.64 | 0.40, 1.02 |
| MRC | ||||
| Favorable* | 73 | 50 | 1.21 | 0.66, 2.25 |
| NN, -Y only | 104 | 61 | 1.16 | 0.75, 1.81 |
| Others | 81 | 47 | 0.55 | 0.64, 0.88 |
| Intermediate∥ | 0.83 | 0.60, 1.14 | ||
| Adverse¶ | 13 | 17 | 0.59 | 0.26, 1.36 |
Favorable cytogenetics is the presence of t(8;21) or inv(16); bad is the presence of other abnormalities without good or very bad cytogenetic features; very bad is the presence of -5, 5q-, -7, 7q-, complex abnormalities, abn 3q, t(9;22), t(6;9), or abn 11q23, and absence of good cytogenetic features.
Favorable cytogenetics in this grouping system is the presence of inv(16) with/without secondary aberrations; t(8;21) without del(9q) and complex karyotype.
Intermediate cytogenetics is the presence of NN, +8, +6, -Y, del(12p) without presence of unfavorable features.
Unfavorable cytogenetics is the presence of -7, 7q-, -5, 5q-, abn (3q), 9q, 11q, 20q, 21q, 17p, t(6;9), t(9;22), or complex, defined as a clone with at least 3 unrelated abnormalities.
Intermediate is the combination of the NN, -Y only group with the other group.
Adverse cytogenetics in this grouping system is the presence of -7, -5, 5q-, abn (3q), or complex, defined as a clone with at least 5 unrelated abnormalities.