Features of PIM-1, PAX-5, RhoH/TTF, c-MYC, and BCL-6 mutations in AIDS-NHL
Locus . | Mutation frequency per 100 bp (range)* . | Single bp substitutions . | Deletions or insertions . | Transitions-transversions (ratio) . | G+C/A+T (ratio) . |
|---|---|---|---|---|---|
| PIM-1 | 0.08 (0.06-0.11) | 7 | 0 | 4/3 (1.33) | 7/0 |
| PAX-5 | 0.07 (0.06-0.12) | 7 | 2 | 4/3 (1.33) | 6/1 |
| RhoH/TTF | 0.18 (0.06-0.41) | 24 | 3 | 17/7 (2.42) | 9/15 |
| c-MYC† | |||||
| Exon 1/intron 1 | 0.05 (0.04-0.08) | 4 | 0 | 3/1 (3.0) | 3/1 |
| Exon 2 | 0.43 (0.09-1.12) | 20 | 0 | 8/12 (0.66) | 15/5 |
| All genes (PIM-1, PAX-5, RhoH/TTF, c-MYC) | NA | 62 | 5 | 36/26 (1.38) | 40/22 (1.82) |
| P < .0001 | |||||
| BCL-6 | 0.20 (0.07-1.08) | 71 | 5 | 36/35 (1.03) | 38/33 |
Locus . | Mutation frequency per 100 bp (range)* . | Single bp substitutions . | Deletions or insertions . | Transitions-transversions (ratio) . | G+C/A+T (ratio) . |
|---|---|---|---|---|---|
| PIM-1 | 0.08 (0.06-0.11) | 7 | 0 | 4/3 (1.33) | 7/0 |
| PAX-5 | 0.07 (0.06-0.12) | 7 | 2 | 4/3 (1.33) | 6/1 |
| RhoH/TTF | 0.18 (0.06-0.41) | 24 | 3 | 17/7 (2.42) | 9/15 |
| c-MYC† | |||||
| Exon 1/intron 1 | 0.05 (0.04-0.08) | 4 | 0 | 3/1 (3.0) | 3/1 |
| Exon 2 | 0.43 (0.09-1.12) | 20 | 0 | 8/12 (0.66) | 15/5 |
| All genes (PIM-1, PAX-5, RhoH/TTF, c-MYC) | NA | 62 | 5 | 36/26 (1.38) | 40/22 (1.82) |
| P < .0001 | |||||
| BCL-6 | 0.20 (0.07-1.08) | 71 | 5 | 36/35 (1.03) | 38/33 |
NA indicates not applicable.
Mutation frequencies were calculated on the entire region analyzed and on mutated cases only, considering 2 alleles/gene/case.
Mutations of c-MYC exon 1 and exon 2 were considered only if they occurred in AIDS-NHL devoid of gross rearrangements of the gene to the immunoglobulin loci.