Frequency of genotypes of single nucleotide polymorphisms of coagulation factor genes and relative risk of myocardial infarction (as measured by odds ratios) in Italians (aged 45 years or younger) and in Canadians (aged 50 years or older)
. | Italians . | . | . | Canadians . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Polymorphism and gene . | Cases, n = 1210 . | Controls, n = 1210 . | Odds ratio . | Cases, n = 500 . | Controls, n = 500 . | Odds ratio . | ||||
| 20210 G > A, factor II | ||||||||||
| 0/0 | 96.7 | 96.8 | 96.8 | 99.0 | ||||||
| 0/1 | 3.3 | 3.1 | 1.0 | 3.2 | 1.0 | 3.3 (P = .015) | ||||
| 1/1 | 0 | 0.1 | (NS) | 0 | 0 | 5.6* (P = .04) | ||||
| 1691G > A, factor V | ||||||||||
| 0/0 | 96.9 | 96.4 | 95.4 | 95.4 | ||||||
| 0/1 | 3.1 | 3.6 | 1.1 | 4.6 | 4.6 | 1.0 (NS) | ||||
| 1/1 | 0 | 0 | (NS) | 0 | 0 | 3.0* (P = .007) | ||||
| 185G > T, factor XIII-A | ||||||||||
| 0/0 | 64.4 | 65.2 | 53.0 | 52.2 | ||||||
| 0/1 | 31.0 | 30.0 | 1.1 | 38.6 | 41.4 | 0.97 (NS) | ||||
| 1/1 | 4.6 | 4.8 | (NS) | 8.4 | 6.4 | 0.8* (NS) | ||||
. | Italians . | . | . | Canadians . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Polymorphism and gene . | Cases, n = 1210 . | Controls, n = 1210 . | Odds ratio . | Cases, n = 500 . | Controls, n = 500 . | Odds ratio . | ||||
| 20210 G > A, factor II | ||||||||||
| 0/0 | 96.7 | 96.8 | 96.8 | 99.0 | ||||||
| 0/1 | 3.3 | 3.1 | 1.0 | 3.2 | 1.0 | 3.3 (P = .015) | ||||
| 1/1 | 0 | 0.1 | (NS) | 0 | 0 | 5.6* (P = .04) | ||||
| 1691G > A, factor V | ||||||||||
| 0/0 | 96.9 | 96.4 | 95.4 | 95.4 | ||||||
| 0/1 | 3.1 | 3.6 | 1.1 | 4.6 | 4.6 | 1.0 (NS) | ||||
| 1/1 | 0 | 0 | (NS) | 0 | 0 | 3.0* (P = .007) | ||||
| 185G > T, factor XIII-A | ||||||||||
| 0/0 | 64.4 | 65.2 | 53.0 | 52.2 | ||||||
| 0/1 | 31.0 | 30.0 | 1.1 | 38.6 | 41.4 | 0.97 (NS) | ||||
| 1/1 | 4.6 | 4.8 | (NS) | 8.4 | 6.4 | 0.8* (NS) | ||||
0/0 indicates genotypes characterized by the presence of 2 wild-type alleles (values are percentages); 0/1, the presence of 1 wild-type and 1 mutant allele; 1/1, the presence of 2 mutant alleles, and NS, not statistically significant.
The odds ratios obtained in the subgroup of 46 patients 50 years or younger.