Clinical characteristics of patients with and without activating mutations
. | Flt3/ITD N = 15 . | Flt3/ALM N = 7 . | c-kit N = 3 . | N-ras N = 12 . | K-ras N = 7 . | All mutations N = 42 . | No mutation N = 49 . | P (mutation vs. no mutation) . |
|---|---|---|---|---|---|---|---|---|
| Median WBC, × 109/L (range) | 73.8 (4.9-453.1) | 37.5 (2.2-480) | 41 (9-106.7) | 56.8 (4.2-351.2) | 80.8 (1.6-345.2) | 71.4 (1.6-480) | 19.6 (0.5-329) | .005 |
| CR (%) | 6 (40) | 6 (86) | 2 (67) | 7 (58) | 3 (43) | 23 (55) | 34 (76)* | .046 |
| 8-y OS (%) | 2 (13) | 6 (86) | 1 (33) | 4 (33) | 2 (29) | 14 (34) | 28 (57) | .035 |
| HR for death† (P) | 2.5 (0.01) | 0.3 (0.23) | 2.1 (0.33) | 1.7 (0.2) | 3.4 (0.02) | 1.8 (0.04) | — | — |
| Allo-BMT in 1st CR | 1 allo BMT, 0 alive | 4 allo BMT, 4 alive | 1 allo BMT, alive | 4 allo BMT, 3 alive | 1 allo BMT, alive | 10 allo BMT, 8 alive | 11 allo BMT, 8 alive | .68 |
. | Flt3/ITD N = 15 . | Flt3/ALM N = 7 . | c-kit N = 3 . | N-ras N = 12 . | K-ras N = 7 . | All mutations N = 42 . | No mutation N = 49 . | P (mutation vs. no mutation) . |
|---|---|---|---|---|---|---|---|---|
| Median WBC, × 109/L (range) | 73.8 (4.9-453.1) | 37.5 (2.2-480) | 41 (9-106.7) | 56.8 (4.2-351.2) | 80.8 (1.6-345.2) | 71.4 (1.6-480) | 19.6 (0.5-329) | .005 |
| CR (%) | 6 (40) | 6 (86) | 2 (67) | 7 (58) | 3 (43) | 23 (55) | 34 (76)* | .046 |
| 8-y OS (%) | 2 (13) | 6 (86) | 1 (33) | 4 (33) | 2 (29) | 14 (34) | 28 (57) | .035 |
| HR for death† (P) | 2.5 (0.01) | 0.3 (0.23) | 2.1 (0.33) | 1.7 (0.2) | 3.4 (0.02) | 1.8 (0.04) | — | — |
| Allo-BMT in 1st CR | 1 allo BMT, 0 alive | 4 allo BMT, 4 alive | 1 allo BMT, alive | 4 allo BMT, 3 alive | 1 allo BMT, alive | 10 allo BMT, 8 alive | 11 allo BMT, 8 alive | .68 |