Laboratory characteristics of patients with and without activating mutations
. | Flt3/ITD N = 15 . | Flt3/PM N = 7 . | c-kit N = 3 . | N-ras N = 12 . | K-ras N = 7 . | All mutations N = 42 . | No mutation N = 49 . | P (mutation vs. no mutation) . |
|---|---|---|---|---|---|---|---|---|
| Median age, y (range) | 8.3 (3.1-18.7) | 7.3 (2.3-13.3) | 15.2 (13.0-17.6) | 10.6 (1.1-18.7) | 5.5 (0.5-17.9) | 8.2 (0.5-18.7) | 11.2 (0.2-17.2) | .8 |
| Median WBC, × 109/L (range) | 73.8 (4.9-453.1) | 37.5 (2.2-480) | 41 (9-106.7) | 56.8 (4.2-351.2) | 80.8 (1.6-345.2) | 71.4 (1.6-480) | 19.6 (0.5-329) | .005 |
| Marrow blast, % (range) | 89 (48-99) | 84 (25-95) | 62 (57-87) | 78 (40-99) | 87 (57-95) | 87 (25-99) | 70 (5-99) | .003 |
| FAB class | .462 | |||||||
| M0, n (%) | 1 (7) | 0 | 0 | 0 | 0 | 1 (2) | 0 | |
| M1, n (%) | 2 (13) | 2 (29) | 1 (33) | 3 (25) | 2 (29) | 9 (21) | 6 (12) | |
| M2, n (%) | 6 (40) | 0 | 0 | 4 (33) | 1 (14) | 10 (24) | 16 (33) | |
| M3, n (%) | 2 (13) | 2 (29) | 0 | 0 | 0 | 4 (10) | 5 (10) | |
| M4, n (%) | 4 (27) | 1 (14) | 1 (33) | 4 (33) | 2 (29) | 12 (29) | 15 (31) | |
| M5, n (%) | 0 | 1 (14) | 1 (33) | 1 (8) | 2 (29) | 5 (12) | 4 (8) | |
| M6, n (%) | 0 | 0 | 0 | 0 | 0 | 0 | 2 (4) | |
| M7, n (%) | 0 | 1 (14) | 0 | 0 | 0 | 1 (2) | 1 (2) | |
| Karyotype | N = 12 | N = 2 | N = 1 | N = 9 | N = 5 | N = 27 | N = 36 | .688 |
| Normal, n (%) | 5 (47) | 0 | 1 (100) | 4 (44) | 1 (20) | 10 (37) | 10 (28) | |
| t(15;17), n (%) | 2 (17) | 2 (100) | 0 | 0 | 0 | 4 (15) | 4 (11) | |
| t(8;21), n (%) | 1 (8) | 0 | 0 | 3 (33) | 0 | 3 (11) | 5 (14) | |
| Inv 16, n (%) | 1 (8) | 0 | 0 | 0 | 0 | 1 (4) | 5 (14) | |
| Abn 11, n (%) | 0 | 0 | 0 | 1 (11) | 2 (40) | 3 (11) | 5 (14) | |
| -7, n (%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| -5, n (%) | 0 | 0 | 0 | 0 | 0 | 0 | 2 (6) | |
| Other, n (%) | 3 (25) | 0 | 0 | 1 (11) | 2 (40) | 6 (22) | 5 (14) |
. | Flt3/ITD N = 15 . | Flt3/PM N = 7 . | c-kit N = 3 . | N-ras N = 12 . | K-ras N = 7 . | All mutations N = 42 . | No mutation N = 49 . | P (mutation vs. no mutation) . |
|---|---|---|---|---|---|---|---|---|
| Median age, y (range) | 8.3 (3.1-18.7) | 7.3 (2.3-13.3) | 15.2 (13.0-17.6) | 10.6 (1.1-18.7) | 5.5 (0.5-17.9) | 8.2 (0.5-18.7) | 11.2 (0.2-17.2) | .8 |
| Median WBC, × 109/L (range) | 73.8 (4.9-453.1) | 37.5 (2.2-480) | 41 (9-106.7) | 56.8 (4.2-351.2) | 80.8 (1.6-345.2) | 71.4 (1.6-480) | 19.6 (0.5-329) | .005 |
| Marrow blast, % (range) | 89 (48-99) | 84 (25-95) | 62 (57-87) | 78 (40-99) | 87 (57-95) | 87 (25-99) | 70 (5-99) | .003 |
| FAB class | .462 | |||||||
| M0, n (%) | 1 (7) | 0 | 0 | 0 | 0 | 1 (2) | 0 | |
| M1, n (%) | 2 (13) | 2 (29) | 1 (33) | 3 (25) | 2 (29) | 9 (21) | 6 (12) | |
| M2, n (%) | 6 (40) | 0 | 0 | 4 (33) | 1 (14) | 10 (24) | 16 (33) | |
| M3, n (%) | 2 (13) | 2 (29) | 0 | 0 | 0 | 4 (10) | 5 (10) | |
| M4, n (%) | 4 (27) | 1 (14) | 1 (33) | 4 (33) | 2 (29) | 12 (29) | 15 (31) | |
| M5, n (%) | 0 | 1 (14) | 1 (33) | 1 (8) | 2 (29) | 5 (12) | 4 (8) | |
| M6, n (%) | 0 | 0 | 0 | 0 | 0 | 0 | 2 (4) | |
| M7, n (%) | 0 | 1 (14) | 0 | 0 | 0 | 1 (2) | 1 (2) | |
| Karyotype | N = 12 | N = 2 | N = 1 | N = 9 | N = 5 | N = 27 | N = 36 | .688 |
| Normal, n (%) | 5 (47) | 0 | 1 (100) | 4 (44) | 1 (20) | 10 (37) | 10 (28) | |
| t(15;17), n (%) | 2 (17) | 2 (100) | 0 | 0 | 0 | 4 (15) | 4 (11) | |
| t(8;21), n (%) | 1 (8) | 0 | 0 | 3 (33) | 0 | 3 (11) | 5 (14) | |
| Inv 16, n (%) | 1 (8) | 0 | 0 | 0 | 0 | 1 (4) | 5 (14) | |
| Abn 11, n (%) | 0 | 0 | 0 | 1 (11) | 2 (40) | 3 (11) | 5 (14) | |
| -7, n (%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| -5, n (%) | 0 | 0 | 0 | 0 | 0 | 0 | 2 (6) | |
| Other, n (%) | 3 (25) | 0 | 0 | 1 (11) | 2 (40) | 6 (22) | 5 (14) |