Table 2. Frequency of somatic mutations... | American Society of Hematology

Table 2.

Frequency of somatic mutations observed in the various heterozygous animals assayed (B220⁺PNA^high and B220⁺PNA^low Peyer patch populations)

	a^wt/b^wt control mice			a^Δhs3b/hs4/b^wt mice
Mutation frequency, per 1000 bp	a allotype	b allotype	a allotype	b allotype
PNA^high cells
FR4 + intron	16.7	14.5	21.75	10.84
Intron only	14.7	14.2	14.0	14.0
In-frame junctions/total	17/31	11/16	5/28	22/26
Total bp analyzed	6820	3520	6160	5720
PNA^low cells
FR4 + intron	3	0	2.9	3.0
Intron only	1.9	0	1.01	1.14
In-frame junctions/total	3/3	2/4	11/27	10/24
Total bp analyzed	660	880	5940	5280

	a^wt/b^wt control mice			a^Δhs3b/hs4/b^wt mice
Mutation frequency, per 1000 bp	a allotype	b allotype	a allotype	b allotype
PNA^high cells
FR4 + intron	16.7	14.5	21.75	10.84
Intron only	14.7	14.2	14.0	14.0
In-frame junctions/total	17/31	11/16	5/28	22/26
Total bp analyzed	6820	3520	6160	5720
PNA^low cells
FR4 + intron	3	0	2.9	3.0
Intron only	1.9	0	1.01	1.14
In-frame junctions/total	3/3	2/4	11/27	10/24
Total bp analyzed	660	880	5940	5280