Characteristics of CALM-AF10+ T-ALLs
UPN . | Sex/age, y . | AF10 nucleotide . | Phenotype . | WBC . | Med . | H/S . | Clinical course . | CALM-AF10 FISH . | Karyotype . |
|---|---|---|---|---|---|---|---|---|---|
| 3489 | M/33 | 424 | TCRγδ | 105 | Neg | Neg | CR, alive 46 mo | Positive | 46, XY, t(10;11)(p13;q14) [11] |
| 3749 | M/29 | 589 | TCRγδ | 42 | Neg | Pos | CR, alive 48 mo | Positive | 46, XY, t(10;11)(p14;q21), t(7;14)(p15;q11), add(18)(q23) [11] |
| 2577 | M/20 | 883/979 | TCRγδ | 30 | Neg | Neg | CR, alive 64 mo | ND | Failed |
| 4105 | M/15 | 589 | TCRγδ | 46 | Neg | Pos | CR, alive 8 mo | ND | 46, XY, del(3)(q12q26), add(4)(q28), add(5)(q23), del(6)(q15qter), der(9)t(9;?)(p21;?), t(10;11)(p13;q14), -13, +mar [7] |
| 4092 | F/11 | 589 | TCRγδ | 39 | Pos | Pos | CR, alive 18 mo | Positive | 46, XX, t(10;11)(p13-14)(q14-21) [13] |
| 4562 | M/7 | ND | TCRγδ | 77 | Pos | Pos | CR, alive 42 mo | Positive | Normal [20] |
| 2726 | M/6 | 589 | TCRγδ | 60 | Neg | Neg | CR, alive 26 mo | ND | Failed |
| 94 | M/3 | 424 | TCRγδ | 350 | Pos | Pos | CR, alive 115 mo | Positive | Failed |
| 4158 | M/43 | 589 | IMγ | 4.5 | Neg | Neg | NR, D (37 mo) | ND | 45, X, -Y, del(1)(q41), del(11)(q21), add(14)(q32), der(17)i(17)(q?10) [12] |
| 3472 | M/37 | 883/979 | IMγ | 3.3 | Neg | Neg | CR, Rel, D (27 mo) | ND | 46, XY, add(9)(p13), t(10;11)(p14;q14) [11] |
| 3188 | M/28 | 883/979 | IMγ | 33 | Neg | Neg | CR-BMT, alive 24 mo | Positive | 46, XY, del(8)(q?22), t(10;11)(p13;q14) [4] |
| 634 | M/26 | 424 | IMγ | 11 | Pos | Neg | CR, Rel, D (30 mo) | ND | Normal [21] |
| 1439 | M/25 | 883/979 | IMγ | 22 | Neg | Pos | CR, Rel, D (18 mo) | Positive | 46, XY, ins(10;11)(p14;q14q25) [15] |
| 4336 | F/25 | 883/979 | IMδ | 220 | Neg | Pos | CR-BMT, Rel, D (11 mo) | Positive | 46, XX, t(10;11)(p12-13;q13-14) [18] |
| 1666 | M/24 | 883/979 | IMγ | 10 | Pos | ND | CR, Rel, BMT, Rel, D (30 mo) | Positive | 46, XY, -6, t(10;11)(p14;q14-21), -20, +2 mars [38] |
| 1488 | M/23 | 424 | IMγ | 9.4 | Pos | Pos | NR, D (3 mo) | ND | 45, XY, -7 [19] |
| 4396 | F/20 | 883/979 | IMγ | 49 | Neg | Neg | CR-BMT, Rel, D (18 mo) | Positive | 46, XX, t(10;11)(p12-13;q13-14) [10] |
| 1978 | M/14 | 883/979 | IMδ | ND | Neg | Neg | CR-BMT, alive 84 mo | ND | 92, XXYY, t(10;11)(p14;q14), i(?17q) [13] |
| 738 | F/12 | 883/979 | IMδ | 124 | Pos | Neg | CR, Rel, in therapy | ND | 47, XX, +8, t(10;11)(p12-14;q14-21) [8] |
| 269 | F/12 | 883/979 | IMγ | 556 | Pos | Pos | CR, Rel, CR, Rel, D (30 mo) | ND | Normal [20] |
UPN . | Sex/age, y . | AF10 nucleotide . | Phenotype . | WBC . | Med . | H/S . | Clinical course . | CALM-AF10 FISH . | Karyotype . |
|---|---|---|---|---|---|---|---|---|---|
| 3489 | M/33 | 424 | TCRγδ | 105 | Neg | Neg | CR, alive 46 mo | Positive | 46, XY, t(10;11)(p13;q14) [11] |
| 3749 | M/29 | 589 | TCRγδ | 42 | Neg | Pos | CR, alive 48 mo | Positive | 46, XY, t(10;11)(p14;q21), t(7;14)(p15;q11), add(18)(q23) [11] |
| 2577 | M/20 | 883/979 | TCRγδ | 30 | Neg | Neg | CR, alive 64 mo | ND | Failed |
| 4105 | M/15 | 589 | TCRγδ | 46 | Neg | Pos | CR, alive 8 mo | ND | 46, XY, del(3)(q12q26), add(4)(q28), add(5)(q23), del(6)(q15qter), der(9)t(9;?)(p21;?), t(10;11)(p13;q14), -13, +mar [7] |
| 4092 | F/11 | 589 | TCRγδ | 39 | Pos | Pos | CR, alive 18 mo | Positive | 46, XX, t(10;11)(p13-14)(q14-21) [13] |
| 4562 | M/7 | ND | TCRγδ | 77 | Pos | Pos | CR, alive 42 mo | Positive | Normal [20] |
| 2726 | M/6 | 589 | TCRγδ | 60 | Neg | Neg | CR, alive 26 mo | ND | Failed |
| 94 | M/3 | 424 | TCRγδ | 350 | Pos | Pos | CR, alive 115 mo | Positive | Failed |
| 4158 | M/43 | 589 | IMγ | 4.5 | Neg | Neg | NR, D (37 mo) | ND | 45, X, -Y, del(1)(q41), del(11)(q21), add(14)(q32), der(17)i(17)(q?10) [12] |
| 3472 | M/37 | 883/979 | IMγ | 3.3 | Neg | Neg | CR, Rel, D (27 mo) | ND | 46, XY, add(9)(p13), t(10;11)(p14;q14) [11] |
| 3188 | M/28 | 883/979 | IMγ | 33 | Neg | Neg | CR-BMT, alive 24 mo | Positive | 46, XY, del(8)(q?22), t(10;11)(p13;q14) [4] |
| 634 | M/26 | 424 | IMγ | 11 | Pos | Neg | CR, Rel, D (30 mo) | ND | Normal [21] |
| 1439 | M/25 | 883/979 | IMγ | 22 | Neg | Pos | CR, Rel, D (18 mo) | Positive | 46, XY, ins(10;11)(p14;q14q25) [15] |
| 4336 | F/25 | 883/979 | IMδ | 220 | Neg | Pos | CR-BMT, Rel, D (11 mo) | Positive | 46, XX, t(10;11)(p12-13;q13-14) [18] |
| 1666 | M/24 | 883/979 | IMγ | 10 | Pos | ND | CR, Rel, BMT, Rel, D (30 mo) | Positive | 46, XY, -6, t(10;11)(p14;q14-21), -20, +2 mars [38] |
| 1488 | M/23 | 424 | IMγ | 9.4 | Pos | Pos | NR, D (3 mo) | ND | 45, XY, -7 [19] |
| 4396 | F/20 | 883/979 | IMγ | 49 | Neg | Neg | CR-BMT, Rel, D (18 mo) | Positive | 46, XX, t(10;11)(p12-13;q13-14) [10] |
| 1978 | M/14 | 883/979 | IMδ | ND | Neg | Neg | CR-BMT, alive 84 mo | ND | 92, XXYY, t(10;11)(p14;q14), i(?17q) [13] |
| 738 | F/12 | 883/979 | IMδ | 124 | Pos | Neg | CR, Rel, in therapy | ND | 47, XX, +8, t(10;11)(p12-14;q14-21) [8] |
| 269 | F/12 | 883/979 | IMγ | 556 | Pos | Pos | CR, Rel, CR, Rel, D (30 mo) | ND | Normal [20] |
CALM-AF10 FISH positivity refers to a split of the CALM signals and colocalization with the AF10 FITC signal
UPN indicates unique patient number; WBC, leukocytosis at presentation; Med, mediastinal mass; H/S, hepatosplenomegaly; CR, complete remission; D, deceased (time); Rel, relapse; BMT, bone marrow transplantation