Effects of inhaled nitric oxide (NO) on hematologic parameters and cell cation content in SAD mice exposed to hypoxia
. | . | Hypoxia, 4 h . | . | Hypoxia, 10 h . | . | Hypoxia, 46 h . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | Baseline . | HY . | HY + NO 40 ppm . | HY . | HY + NO 40 ppm . | HY . | HY + NO 40 ppm . | |||
| Hct, % | 43.0±1.1 | 42.7±1.5 | 43.8±0.2 | 42.7±1.1 | 42.9±1.2 | 43.3±1.5 | 42.2±1.4 | |||
| Hb, g/dL | 12.9±0.4 | 12.5±0.4 | 12.2±1.5 | 13.1±0.5 | 11.9±0.9 | 13.1±0.3 | 12.5±0.4 | |||
| MetHb, % | <1 | <1 | <1 | <1 | <1 | <1 | <1 | |||
| Reticulocytes, % | 6.3±0.4 | 5.8±1.2 | 6.1±0.9 | 7.4±2.1 | 6.9±1.5 | 7.2±0.5 | 5.9±1.4 | |||
| Cell Na, mM/kg Hb | 38.9±4.9 | — | — | — | — | 40.1±5.7 | 36.0±7.3 | |||
| Cell K, mM/kg Hb | 340±22.3 | — | — | — | — | 283±13.7* | 309.1±17.2*† | |||
. | . | Hypoxia, 4 h . | . | Hypoxia, 10 h . | . | Hypoxia, 46 h . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | Baseline . | HY . | HY + NO 40 ppm . | HY . | HY + NO 40 ppm . | HY . | HY + NO 40 ppm . | |||
| Hct, % | 43.0±1.1 | 42.7±1.5 | 43.8±0.2 | 42.7±1.1 | 42.9±1.2 | 43.3±1.5 | 42.2±1.4 | |||
| Hb, g/dL | 12.9±0.4 | 12.5±0.4 | 12.2±1.5 | 13.1±0.5 | 11.9±0.9 | 13.1±0.3 | 12.5±0.4 | |||
| MetHb, % | <1 | <1 | <1 | <1 | <1 | <1 | <1 | |||
| Reticulocytes, % | 6.3±0.4 | 5.8±1.2 | 6.1±0.9 | 7.4±2.1 | 6.9±1.5 | 7.2±0.5 | 5.9±1.4 | |||
| Cell Na, mM/kg Hb | 38.9±4.9 | — | — | — | — | 40.1±5.7 | 36.0±7.3 | |||
| Cell K, mM/kg Hb | 340±22.3 | — | — | — | — | 283±13.7* | 309.1±17.2*† | |||
Data are presented as means ± SEM of 6 experiments. HY indicates hypoxia (8% oxygen); MetHb, methemoglobin; and —, not done
P<.05 compared with baseline, as determined by ANOVA with post hoc Bonferroni corrected t test
P<.05 compared with hypoxia group, as determined by ANOVA with post hoc Bonferroni corrected t test