Biochemical and laboratory findings of 30 HCV+, t(14;18)+ CLD patients before and after treatment with IFNα plus ribavirin
. | . | . | . | . | Before . | . | . | . | After . | . | . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. . | Age . | Sex . | Liver histology . | HCV genotype . | ALT × ULN level . | Serum* HCV RNA titer . | BL HCV RNA . | t(14;18) . | ALT × ULN level . | Serum* HCV RNA titer . | BL HCV RNA . | t(14;18) . | ||||||
1 | 47 | M | CH | 1b | 7.75 | 1.2 × 106 | + | + | 0.75 | 5.7 × 103 | + | - | ||||||
2 | 37 | M | CH | 1b | 2.60 | 1.0 × 106 | + | + | 0.88 | 6.4 × 103 | + | - | ||||||
3 | 42 | F | CH | 1b | 3.08 | 3.4 × 106 | + | + | 0.45 | - | - | - | ||||||
4 | 46 | F | CH | 1b | 1.75 | 6.3 × 105 | + | + | 1.90 | 4.7 × 105 | + | + | ||||||
5 | 52 | M | C | 1b | 1.95 | 5.0 × 105 | + | + | 0.20 | - | - | - | ||||||
6 | 53 | M | CH | 2a/c | 2.30 | +ND | + | + | 0.53 | - | - | - | ||||||
7 | 55 | M | C | 1b | 7.43 | 3.0 × 106 | + | + | 1.30 | 2.8 × 106 | - | + | ||||||
8 | 39 | M | CH | 3a | 4.68 | 2.5 × 106 | - | + | 0.63 | 5.3 × 103 | - | + | ||||||
9 | 57 | M | C | 1b | 4.40 | 1.2 × 105 | + | + | 0.48 | 7.0 × 103 | - | + | ||||||
10 | 62 | M | C | 2a/c | 3.00 | 2.0 × 106 | + | + | 4.03 | 1.5 × 106 | + | + | ||||||
11 | 66 | F | CH | 1b | 7.88 | 1.0 × 106 | + | + | 0.95 | - | + | - | ||||||
12 | 51 | F | CH | 1b | 8.03 | 2.5 × 106 | + | + | 0.18 | - | ND | - | ||||||
13 | 39 | M | C | 1b | 6.25 | 3.0 × 106 | + | + | 0.93 | 5.0 × 104 | - | - | ||||||
14 | 45 | M | C | 1b | 7.98 | +ND | + | + | 0.35 | - | + | + | ||||||
15 | 62 | M | C | 1b | 0.98 | 1.5 × 106 | + | + | 0.55 | - | - | - | ||||||
16 | 37 | M | CH | 2a/c | 2.13 | 1.5 × 106 | + | + | 1.05 | 9.0 × 105 | + | + | ||||||
17 | 57 | F | C | 1b | 5.08 | 1.0 × 106 | + | + | 1.00 | 5.5 × 103 | + | - | ||||||
18 | 38 | M | CH | 3a | 1.88 | 7.0 × 105 | + | + | 2.25 | 5.0 × 105 | - | + | ||||||
19 | 38 | F | CH | 1b/c | 2.53 | 3.0 × 106 | + | + | 0.70 | 5.0 × 105 | + | - | ||||||
20 | 53 | M | CH | 1b | 2.15 | 1.5 × 106 | + | + | 0.33 | - | + | + | ||||||
21 | 47 | M | C | 1b | 2.75 | 1.6 × 105 | + | + | 0.80 | - | - | - | ||||||
22 | 56 | F | CH | 2a/c | 1.13 | 1.0 × 106 | + | + | 0.68 | - | - | + | ||||||
23 | 60 | M | C | 1b | 2.50 | 2.8 × 106 | + | + | 1.88 | 1.8 × 106 | + | + | ||||||
24 | 36 | F | CH | 3a | 0.53 | 2.5 × 105 | + | + | 0.35 | - | - | + | ||||||
25 | 52 | F | CH | 2a/c | 8.53 | 3.0 × 106 | + | + | 0.33 | 4.0 × 104 | - | - | ||||||
26 | 41 | M | CH | 2a/c | 2.80 | 2.5 × 106 | + | + | 0.30 | - | + | + | ||||||
27 | 45 | F | CH | 2a/c | 2.70 | 1.0 × 106 | + | + | 0.53 | - | - | - | ||||||
28 | 60 | M | C | 1b | 2.60 | 4.4 × 106 | + | + | 0.75 | 2.9 × 104 | + | + | ||||||
29 | 57 | F | CH | 2a/c | 0.50 | 3.4 × 106 | + | + | 0.30 | 5.7 × 103 | + | + | ||||||
30 | 47 | F | CH | 1b | 3.10 | 1.2 × 106 | ND | + | 0.95 | - | ND | - |
. | . | . | . | . | Before . | . | . | . | After . | . | . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. . | Age . | Sex . | Liver histology . | HCV genotype . | ALT × ULN level . | Serum* HCV RNA titer . | BL HCV RNA . | t(14;18) . | ALT × ULN level . | Serum* HCV RNA titer . | BL HCV RNA . | t(14;18) . | ||||||
1 | 47 | M | CH | 1b | 7.75 | 1.2 × 106 | + | + | 0.75 | 5.7 × 103 | + | - | ||||||
2 | 37 | M | CH | 1b | 2.60 | 1.0 × 106 | + | + | 0.88 | 6.4 × 103 | + | - | ||||||
3 | 42 | F | CH | 1b | 3.08 | 3.4 × 106 | + | + | 0.45 | - | - | - | ||||||
4 | 46 | F | CH | 1b | 1.75 | 6.3 × 105 | + | + | 1.90 | 4.7 × 105 | + | + | ||||||
5 | 52 | M | C | 1b | 1.95 | 5.0 × 105 | + | + | 0.20 | - | - | - | ||||||
6 | 53 | M | CH | 2a/c | 2.30 | +ND | + | + | 0.53 | - | - | - | ||||||
7 | 55 | M | C | 1b | 7.43 | 3.0 × 106 | + | + | 1.30 | 2.8 × 106 | - | + | ||||||
8 | 39 | M | CH | 3a | 4.68 | 2.5 × 106 | - | + | 0.63 | 5.3 × 103 | - | + | ||||||
9 | 57 | M | C | 1b | 4.40 | 1.2 × 105 | + | + | 0.48 | 7.0 × 103 | - | + | ||||||
10 | 62 | M | C | 2a/c | 3.00 | 2.0 × 106 | + | + | 4.03 | 1.5 × 106 | + | + | ||||||
11 | 66 | F | CH | 1b | 7.88 | 1.0 × 106 | + | + | 0.95 | - | + | - | ||||||
12 | 51 | F | CH | 1b | 8.03 | 2.5 × 106 | + | + | 0.18 | - | ND | - | ||||||
13 | 39 | M | C | 1b | 6.25 | 3.0 × 106 | + | + | 0.93 | 5.0 × 104 | - | - | ||||||
14 | 45 | M | C | 1b | 7.98 | +ND | + | + | 0.35 | - | + | + | ||||||
15 | 62 | M | C | 1b | 0.98 | 1.5 × 106 | + | + | 0.55 | - | - | - | ||||||
16 | 37 | M | CH | 2a/c | 2.13 | 1.5 × 106 | + | + | 1.05 | 9.0 × 105 | + | + | ||||||
17 | 57 | F | C | 1b | 5.08 | 1.0 × 106 | + | + | 1.00 | 5.5 × 103 | + | - | ||||||
18 | 38 | M | CH | 3a | 1.88 | 7.0 × 105 | + | + | 2.25 | 5.0 × 105 | - | + | ||||||
19 | 38 | F | CH | 1b/c | 2.53 | 3.0 × 106 | + | + | 0.70 | 5.0 × 105 | + | - | ||||||
20 | 53 | M | CH | 1b | 2.15 | 1.5 × 106 | + | + | 0.33 | - | + | + | ||||||
21 | 47 | M | C | 1b | 2.75 | 1.6 × 105 | + | + | 0.80 | - | - | - | ||||||
22 | 56 | F | CH | 2a/c | 1.13 | 1.0 × 106 | + | + | 0.68 | - | - | + | ||||||
23 | 60 | M | C | 1b | 2.50 | 2.8 × 106 | + | + | 1.88 | 1.8 × 106 | + | + | ||||||
24 | 36 | F | CH | 3a | 0.53 | 2.5 × 105 | + | + | 0.35 | - | - | + | ||||||
25 | 52 | F | CH | 2a/c | 8.53 | 3.0 × 106 | + | + | 0.33 | 4.0 × 104 | - | - | ||||||
26 | 41 | M | CH | 2a/c | 2.80 | 2.5 × 106 | + | + | 0.30 | - | + | + | ||||||
27 | 45 | F | CH | 2a/c | 2.70 | 1.0 × 106 | + | + | 0.53 | - | - | - | ||||||
28 | 60 | M | C | 1b | 2.60 | 4.4 × 106 | + | + | 0.75 | 2.9 × 104 | + | + | ||||||
29 | 57 | F | CH | 2a/c | 0.50 | 3.4 × 106 | + | + | 0.30 | 5.7 × 103 | + | + | ||||||
30 | 47 | F | CH | 1b | 3.10 | 1.2 × 106 | ND | + | 0.95 | - | ND | - |
ALT indicates alanine aminotransferase as multiple of upper limit of normal values (× ULN); BL, peripheral B lymphocyte; and ND, not done.
All HCV RNA titers are expressed as HCV copies/mL.