Univariate and multivariable analysis of risk factors for invasive mold infections after allogeneic HCT with nonmyeloablative conditioning
Variables . | Univariate analysis HR (95% CI) . | Univariate analysis P . | Multivariable analysis HR (95% CI) . | Multivariable analysis P . |
|---|---|---|---|---|
| Acute GVHD grades III-IV | 7.1 (3.1-16.1) | <.0001 | 2.8 (1.1-6.9) | .04 |
| Acute GVHD grades II-IV | 4.7 (1.6-14.3) | .001 | — | — |
| Chronic extensive GVHD | 5.7 (1.7-19.1) | <.002 | 3.7 (1.0-13.9) | .04 |
| Corticosteroids (2 mg/kg or more) | 4.0 (1.7-9.6) | .0009 | — | — |
| CMV antigenemia | 2.9 (1.3-6.7) | .01 | — | — |
| CMV disease | 32.9 (12.6-85.8) | <.0001 | 13.3 (4.7-37.7) | <.0001 |
| Lymphopenia (less than 300/mm3) | 2.2 (1.0-5.0) | 0.05 | — | — |
Variables . | Univariate analysis HR (95% CI) . | Univariate analysis P . | Multivariable analysis HR (95% CI) . | Multivariable analysis P . |
|---|---|---|---|---|
| Acute GVHD grades III-IV | 7.1 (3.1-16.1) | <.0001 | 2.8 (1.1-6.9) | .04 |
| Acute GVHD grades II-IV | 4.7 (1.6-14.3) | .001 | — | — |
| Chronic extensive GVHD | 5.7 (1.7-19.1) | <.002 | 3.7 (1.0-13.9) | .04 |
| Corticosteroids (2 mg/kg or more) | 4.0 (1.7-9.6) | .0009 | — | — |
| CMV antigenemia | 2.9 (1.3-6.7) | .01 | — | — |
| CMV disease | 32.9 (12.6-85.8) | <.0001 | 13.3 (4.7-37.7) | <.0001 |
| Lymphopenia (less than 300/mm3) | 2.2 (1.0-5.0) | 0.05 | — | — |
Other variables examined included patient age, patient sex, underlying disease risk, donor, stem cell source, conditioning including fludarabine, prior history of HCT, CMV risk group, season of transplantation, neutropenia, and monocytopenia
— indicates not significant in the multivariate model