Unifactor analyses of overall survival by prognostic factors
Variable . | Patients, no. . | Estimated median survival, months . | Relative hazard rate (95% CI) . | P, log rank . |
|---|---|---|---|---|
| Age, years | ||||
| 65 or younger | 39 | > 26.3 | 1.00 | .002 |
| Older than 65 | 36 | 9.2 | 2.77 (1.42-5.38) | |
| β2-microglobulin level | ||||
| 3 mg/L or lower | 18 | > 25.8 | 1.00 | .0008‡ |
| Above 3 mg/L but lower than 6 mg/L | 30 | 15.7 | 2.59 (0.85-7.84) | |
| At least 6 mg/L | 27 | 8.5 | 5.17 (1.74-15.40) | |
| LDH level* | ||||
| ULN or lower | 56 | 20.1 | 1.00 | .0006 |
| Greater than ULN | 18 | 8.0 | 3.17 (1.58-6.35) | |
| Hemoglobin level | ||||
| 110 g/L or higher | 37 | 15.7 | 1.00 | .51 |
| Below 110 g/L | 38 | 12.7 | 1.24 (0.65-2.35) | |
| C-reactive protein level† | ||||
| Below 6 mg/L | 31 | 19.8 | 1.00 | .24‡ |
| Between 6 and 10 mg/L | 13 | 8.5 | 2.15 (0.92-5.04) | |
| Above 10 mg/L | 24 | 10.9 | 1.54 (0.71-3.33) | |
| Serum creatinine level | ||||
| 0.13 mM or lower | 57 | 19.8 | 1.00 | .001 |
| Above 0.13 mM | 18 | 6.8 | 3.05 (1.52-6.13) | |
| Calcium level† | ||||
| 2.60 mM or lower | 68 | 14.6 | 1.00 | .89 |
| Above 2.60 mM | 5 | 19.0 | 1.09 (0.33-3.55) | |
| Plasma cells in bone marrow† | ||||
| 50% or lower | 53 | 19.0 | 1.00 | .22 |
| Above 50% | 19 | 10.2 | 1.54 (0.77-3.09) | |
| Responded to last prior chemotherapy† | ||||
| No | 46 | 12.7 | 1.35 (0.67-2.71) | |
| Yes | 27 | 20.1 | 1.00 | .40 |
| Chromosome 13 loss† | ||||
| No | 21 | > 26.3 | 1.00 | .003 |
| Yes | 9 | 8.5 | 4.59 (1.50-13.7) |
Variable . | Patients, no. . | Estimated median survival, months . | Relative hazard rate (95% CI) . | P, log rank . |
|---|---|---|---|---|
| Age, years | ||||
| 65 or younger | 39 | > 26.3 | 1.00 | .002 |
| Older than 65 | 36 | 9.2 | 2.77 (1.42-5.38) | |
| β2-microglobulin level | ||||
| 3 mg/L or lower | 18 | > 25.8 | 1.00 | .0008‡ |
| Above 3 mg/L but lower than 6 mg/L | 30 | 15.7 | 2.59 (0.85-7.84) | |
| At least 6 mg/L | 27 | 8.5 | 5.17 (1.74-15.40) | |
| LDH level* | ||||
| ULN or lower | 56 | 20.1 | 1.00 | .0006 |
| Greater than ULN | 18 | 8.0 | 3.17 (1.58-6.35) | |
| Hemoglobin level | ||||
| 110 g/L or higher | 37 | 15.7 | 1.00 | .51 |
| Below 110 g/L | 38 | 12.7 | 1.24 (0.65-2.35) | |
| C-reactive protein level† | ||||
| Below 6 mg/L | 31 | 19.8 | 1.00 | .24‡ |
| Between 6 and 10 mg/L | 13 | 8.5 | 2.15 (0.92-5.04) | |
| Above 10 mg/L | 24 | 10.9 | 1.54 (0.71-3.33) | |
| Serum creatinine level | ||||
| 0.13 mM or lower | 57 | 19.8 | 1.00 | .001 |
| Above 0.13 mM | 18 | 6.8 | 3.05 (1.52-6.13) | |
| Calcium level† | ||||
| 2.60 mM or lower | 68 | 14.6 | 1.00 | .89 |
| Above 2.60 mM | 5 | 19.0 | 1.09 (0.33-3.55) | |
| Plasma cells in bone marrow† | ||||
| 50% or lower | 53 | 19.0 | 1.00 | .22 |
| Above 50% | 19 | 10.2 | 1.54 (0.77-3.09) | |
| Responded to last prior chemotherapy† | ||||
| No | 46 | 12.7 | 1.35 (0.67-2.71) | |
| Yes | 27 | 20.1 | 1.00 | .40 |
| Chromosome 13 loss† | ||||
| No | 21 | > 26.3 | 1.00 | .003 |
| Yes | 9 | 8.5 | 4.59 (1.50-13.7) |