Unifactor analyses of progression-free survival by prognostic factors
Variable . | Patients, no. . | Estimated median survival, months . | Relative hazard rate (95% CI) . | P, log rank . |
|---|---|---|---|---|
| Age, years | ||||
| 65 or younger | 39 | 6.7 | 1.00 | .045 |
| Older than 65 | 36 | 4.1 | 1.66 (1.00-2.74) | |
| β2-microglobulin level | ||||
| 3 mg/L or lower | 18 | 14.6 | 1.00 | .015§ |
| Above 3 mg/L but lower than 6 mg/L | 30 | 3.7 | 2.77 (1.35-5.71) | |
| At least 6 mg/L | 27 | 4.4 | 2.54 (1.23-5.23) | |
| LDH level* | ||||
| ULN or lower | 56 | 6.0 | 1.00 | .003 |
| Greater than ULN | 18 | 1.9 | 2.34 (1.32-4.17) | |
| Hemoglobin level | ||||
| At least 110 g/L | 37 | 5.6 | 1.00 | .58 |
| Below 110 g/L | 38 | 5.0 | 1.15 (0.70-1.89) | |
| C-reactive protein level† | ||||
| Below 6 mg/L | 31 | 6.9 | 1.00 | .060§ |
| Between 6 and 10 mg/L | 13 | 2.2 | 1.82 (0.90-3.68) | |
| Above 10 mg/L | 24 | 4.1 | 1.72 (0.95-3.12) | |
| Serum creatinine level | ||||
| 0.13 mg/L or lower | 57 | 5.7 | 1.00 | .60 |
| Above 0.13 mg/L | 18 | 4.5 | 1.17 (0.65-2.10) | |
| Calcium level† | ||||
| 2.60 mM or lower | 68 | 5.5 | 1.00 | .30 |
| Above 2.60 mM | 5 | 19.0 | 0.59 (0.21-1.65) | |
| Plasma cells in bone marrow† | ||||
| 50% or lower | 53 | 5.6 | 1.00 | .18 |
| Above 50% | 19 | 4.5 | 1.48 (0.83-2.62) | |
| Responded to last prior chemotherapy† | ||||
| No | 46 | 5.6 | 0.96 (0.57-1.62) | |
| Yes | 27 | 4.6 | 1.00 | .88 |
| Chromosome 13 loss‡ | ||||
| No | 21 | 6.6 | 1.00 | .004 |
| Yes | 9 | 3.5 | 3.40 (1.40-8.38) |
Variable . | Patients, no. . | Estimated median survival, months . | Relative hazard rate (95% CI) . | P, log rank . |
|---|---|---|---|---|
| Age, years | ||||
| 65 or younger | 39 | 6.7 | 1.00 | .045 |
| Older than 65 | 36 | 4.1 | 1.66 (1.00-2.74) | |
| β2-microglobulin level | ||||
| 3 mg/L or lower | 18 | 14.6 | 1.00 | .015§ |
| Above 3 mg/L but lower than 6 mg/L | 30 | 3.7 | 2.77 (1.35-5.71) | |
| At least 6 mg/L | 27 | 4.4 | 2.54 (1.23-5.23) | |
| LDH level* | ||||
| ULN or lower | 56 | 6.0 | 1.00 | .003 |
| Greater than ULN | 18 | 1.9 | 2.34 (1.32-4.17) | |
| Hemoglobin level | ||||
| At least 110 g/L | 37 | 5.6 | 1.00 | .58 |
| Below 110 g/L | 38 | 5.0 | 1.15 (0.70-1.89) | |
| C-reactive protein level† | ||||
| Below 6 mg/L | 31 | 6.9 | 1.00 | .060§ |
| Between 6 and 10 mg/L | 13 | 2.2 | 1.82 (0.90-3.68) | |
| Above 10 mg/L | 24 | 4.1 | 1.72 (0.95-3.12) | |
| Serum creatinine level | ||||
| 0.13 mg/L or lower | 57 | 5.7 | 1.00 | .60 |
| Above 0.13 mg/L | 18 | 4.5 | 1.17 (0.65-2.10) | |
| Calcium level† | ||||
| 2.60 mM or lower | 68 | 5.5 | 1.00 | .30 |
| Above 2.60 mM | 5 | 19.0 | 0.59 (0.21-1.65) | |
| Plasma cells in bone marrow† | ||||
| 50% or lower | 53 | 5.6 | 1.00 | .18 |
| Above 50% | 19 | 4.5 | 1.48 (0.83-2.62) | |
| Responded to last prior chemotherapy† | ||||
| No | 46 | 5.6 | 0.96 (0.57-1.62) | |
| Yes | 27 | 4.6 | 1.00 | .88 |
| Chromosome 13 loss‡ | ||||
| No | 21 | 6.6 | 1.00 | .004 |
| Yes | 9 | 3.5 | 3.40 (1.40-8.38) |