Interaction between current estrogen use and total number of copies of factor XIIIA Leu34 and factor XIIIB Arg95 alleles on risk of nonfatal myocardial infarction
Estrogen use . | No. of factor XIII variant alleles* . | No. of cases . | No. of controls . | Odds ratio (95% CI) . | P . | Measure . | Point estimate (95% CI) . | P . |
|---|---|---|---|---|---|---|---|---|
| Not current | < 2 | 135 | 376 | 1.00 (reference) | OR for < 2 copies† | 1.41 (0.96-2.07) | .07 | |
| Current | < 2 | 74 | 218 | 1.40 (0.96-2.04) | .08 | |||
| Not current | ≥ 2 | 19 | 77 | 0.85 (0.47-1.55) | .59 | OR for ≥ 2 copies† | 0.43 (0.14-1.30) | .13 |
| Current | ≥ 2 | 6 | 50 | 0.33 (0.13-0.85) | .02 |
Estrogen use . | No. of factor XIII variant alleles* . | No. of cases . | No. of controls . | Odds ratio (95% CI) . | P . | Measure . | Point estimate (95% CI) . | P . |
|---|---|---|---|---|---|---|---|---|
| Not current | < 2 | 135 | 376 | 1.00 (reference) | OR for < 2 copies† | 1.41 (0.96-2.07) | .07 | |
| Current | < 2 | 74 | 218 | 1.40 (0.96-2.04) | .08 | |||
| Not current | ≥ 2 | 19 | 77 | 0.85 (0.47-1.55) | .59 | OR for ≥ 2 copies† | 0.43 (0.14-1.30) | .13 |
| Current | ≥ 2 | 6 | 50 | 0.33 (0.13-0.85) | .02 |
OR indicates odds ratio; CI, confidence interval. Odds ratios for current estrogen use compared to not current (past or never) use were adjusted for age, race, calendar year, treated hypertension status, current smoking, diabetes, systolic blood pressure, and cholesterol.
Total copy number of factor XIIIA Leu34 and factor XIIIB Arg95 alleles.
Odds ratio for myocardial infarction associated with current estrogen use among subjects with the indicated number of factor XIII variant alleles.