Main effects of estrogen use, factor XIIIA Val34Leu, and factor XIIIB His95Arg on risk of nonfatal myocardial infarction
Exposure . | No. of cases . | No. of controls . | Unadjusted odds ratio (95% CI)* . | Adjusted odds ratio (95% CI)† . |
|---|---|---|---|---|
| Estrogen use | ||||
| Never | 107 | 266 | 1.00 (reference) | 1.00 (reference) |
| Past | 47 | 187 | 0.62 (0.42-0.92) | 0.74 (0.48-1.14) |
| Current | 80 | 268 | 0.74 (0.53-1.04) | 1.05 (0.71-1.54) |
| Current vs not current | 0.88 (0.64-1.20) | 1.17 (0.83-1.67) | ||
| Factor XIIIA genotype | ||||
| Val34/Val34 | 152 | 406 | 1.00 (reference) | 1.00 (reference) |
| Val34/Leu34 | 68 | 260 | 0.70 (0.50-0.97) | 0.70 (0.51-0.97) |
| Leu34/Leu34 | 14 | 55 | 0.68 (0.37-1.26) | 0.69 (0.37-1.27) |
| Any Leu34 | 0.70 (0.51-0.94) | 0.70 (0.51-0.95) | ||
| Factor XIIIB genotype | ||||
| His95/His95 | 193 | 577 | 1.00 (reference) | 1.00 (reference) |
| His/95/Arg95 | 39 | 125 | 0.93 (0.63-1.38) | 0.89 (0.59-1.33) |
| Arg95/Arg95 | 2 | 19 | 0.31 (0.07-1.36) | 0.21 (0.04-1.06) |
| Any Arg95 | 0.85 (0.58-1.25) | 0.82 (0.55-1.22) |
Exposure . | No. of cases . | No. of controls . | Unadjusted odds ratio (95% CI)* . | Adjusted odds ratio (95% CI)† . |
|---|---|---|---|---|
| Estrogen use | ||||
| Never | 107 | 266 | 1.00 (reference) | 1.00 (reference) |
| Past | 47 | 187 | 0.62 (0.42-0.92) | 0.74 (0.48-1.14) |
| Current | 80 | 268 | 0.74 (0.53-1.04) | 1.05 (0.71-1.54) |
| Current vs not current | 0.88 (0.64-1.20) | 1.17 (0.83-1.67) | ||
| Factor XIIIA genotype | ||||
| Val34/Val34 | 152 | 406 | 1.00 (reference) | 1.00 (reference) |
| Val34/Leu34 | 68 | 260 | 0.70 (0.50-0.97) | 0.70 (0.51-0.97) |
| Leu34/Leu34 | 14 | 55 | 0.68 (0.37-1.26) | 0.69 (0.37-1.27) |
| Any Leu34 | 0.70 (0.51-0.94) | 0.70 (0.51-0.95) | ||
| Factor XIIIB genotype | ||||
| His95/His95 | 193 | 577 | 1.00 (reference) | 1.00 (reference) |
| His/95/Arg95 | 39 | 125 | 0.93 (0.63-1.38) | 0.89 (0.59-1.33) |
| Arg95/Arg95 | 2 | 19 | 0.31 (0.07-1.36) | 0.21 (0.04-1.06) |
| Any Arg95 | 0.85 (0.58-1.25) | 0.82 (0.55-1.22) |
Cl indicates confidence interval.
Odds ratios for estrogen use were adjusted for matching variables (age, calendar year, and treated hypertension) and potential confounding variables of race, current smoking, diabetes, cholesterol, and systolic blood pressure.17,19 Odds ratios for factor XIII genotypes were adjusted only for age and race; additional adjustment for smoking status, hypertension, diabetes, or cholesterol level did not appreciably alter the results.