Operating characteristics of clofarabine versus clofarabine + ara-C versus clofarabine + idarubicin trial: within-arm OCs
. | . | Achieved sample size percentiles . | . | . | ||
|---|---|---|---|---|---|---|
| Clinical scenario . | Probability of early termination . | 25th . | 50th . | 75th . | ||
| Same as rate with IA (11% CR, 15% death, 74% neither) | 0.68 | 8 | 16 | 24 | ||
| 26% CR rate, 20% death rate, 54% have neither | 0.17 | 24 | 24 | 24 | ||
| 11% CR rate, 35% death rate, 54% have neither | 0.78 | 8 | 12 | 20 | ||
. | . | Achieved sample size percentiles . | . | . | ||
|---|---|---|---|---|---|---|
| Clinical scenario . | Probability of early termination . | 25th . | 50th . | 75th . | ||
| Same as rate with IA (11% CR, 15% death, 74% neither) | 0.68 | 8 | 16 | 24 | ||
| 26% CR rate, 20% death rate, 54% have neither | 0.17 | 24 | 24 | 24 | ||
| 11% CR rate, 35% death rate, 54% have neither | 0.78 | 8 | 12 | 20 | ||