Table 3.

Operating characteristics of double-induction trial




Achieved sample size percentiles
Clinical scenario
Probability of early termination
25th
50th
75th
Same as historical rates   0.69   15   25   50  
82% success rate and 18% death rate   0.21   50   50   50  
67% success rate and 33% death rate   0.96   10   15   20  
50% ineligibility rate
 
0.89
 
10
 
15
 
30
 



Achieved sample size percentiles
Clinical scenario
Probability of early termination
25th
50th
75th
Same as historical rates   0.69   15   25   50  
82% success rate and 18% death rate   0.21   50   50   50  
67% success rate and 33% death rate   0.96   10   15   20  
50% ineligibility rate
 
0.89
 
10
 
15
 
30
 
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