Table 1. Operating characteristics of... | American Society of Hematology

Table 1.

Operating characteristics of LDA +/- Thal, LDT +/- Thal trial: intra-arm OCs

True CR rate*	Probability of early termination	Achieved sample size percentiles†
True CR rate*	Probability of early termination			25th	50th	75th
39%	0.85	5	10	15
49%	0.59	10	15	20
64%	0.18	20	20	20

True CR rate*	Probability of early termination	Achieved sample size percentiles†
True CR rate*	Probability of early termination			25th	50th	75th
39%	0.85	5	10	15
49%	0.59	10	15	20
64%	0.18	20	20	20

Mean historical CR rate is 49%.

†

For example with a true CR rate of 49%, in 25% of the 10,000 simulated trials, the sample size was 0 to 10, the median sample size was 15, and in another 25% of the trials the sample size was 20, the maximum.

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