Changes in activity values of VWF and FVIII during rhIL-11 and DDAVP treatment
. | Treatment . | . | VWF . | . | FVIII . | . | |||
|---|---|---|---|---|---|---|---|---|---|
. | rhIL-11 . | DDAVP . | Heterozygous VWD* . | Normal . | Heterozygous VWD* . | Normal . | |||
| Baseline | - | - | 100 (53) | 100 (106) | 100 (112) | 100 (122) | |||
| Day 1 | + | - | 116 (61) | 94 (100) | 99 (111) | 101 (123) | |||
| Day 6 | + | + | 317 (169) | 391 (414) | 205 (229) | 245 (299) | |||
| Day 7 | + | + | 311 (165) | 375 (397) | 184 (205) | 195 (237) | |||
| Day 14 | - | + | 207 (110) | 210 (223) | 173 (193) | 216 (157) | |||
. | Treatment . | . | VWF . | . | FVIII . | . | |||
|---|---|---|---|---|---|---|---|---|---|
. | rhIL-11 . | DDAVP . | Heterozygous VWD* . | Normal . | Heterozygous VWD* . | Normal . | |||
| Baseline | - | - | 100 (53) | 100 (106) | 100 (112) | 100 (122) | |||
| Day 1 | + | - | 116 (61) | 94 (100) | 99 (111) | 101 (123) | |||
| Day 6 | + | + | 317 (169) | 391 (414) | 205 (229) | 245 (299) | |||
| Day 7 | + | + | 311 (165) | 375 (397) | 184 (205) | 195 (237) | |||
| Day 14 | - | + | 207 (110) | 210 (223) | 173 (193) | 216 (157) | |||
Activity values are reported as percentage of baseline; actual values are shown in parentheses. Measurements were made at 30 minutes after treatment. + indicates given; -, not given.
Average of 2 heterozygous VWD dogs.