ATRA-regulated genes involved in TNF signaling as determined by microarray analysis
Gene . | 2 h . | 24 h . | 96 h . |
|---|---|---|---|
| TNF-inducible protein TSG-6 precursor | — | — | Pos |
| NF-kB precursor p 105 | — | — | Pos |
| Trail receptor 2 | Pos | — | Pos |
| Toll-like receptor 3 | — | — | Pos |
| Dif-2 | Pos | — | — |
| BCL2-related protein A1 | Pos | Pos | — |
| TNF receptor 2 (75 kDa) | — | Pos | — |
| TNF receptor superfamily member 10b (TNFRSF10B) | Pos | — | — |
| STAT1α | — | — | Pos |
| TNF ligand superfamily member 7 (TNFSF7, CD70) | Pos | Pos | — |
| BCL-3 | — | Pos | — |
| TNF-α-induced protein 2 (TNFAIP2) | Pos | Pos | — |
| Phosphatidylinositol 3-kinase, γ-polypeptide | — | Pos | Pos |
| FIP2 TNF-α-inducible protein | Pos | Pos | — |
| A20 | Neg | Neg | — |
Gene . | 2 h . | 24 h . | 96 h . |
|---|---|---|---|
| TNF-inducible protein TSG-6 precursor | — | — | Pos |
| NF-kB precursor p 105 | — | — | Pos |
| Trail receptor 2 | Pos | — | Pos |
| Toll-like receptor 3 | — | — | Pos |
| Dif-2 | Pos | — | — |
| BCL2-related protein A1 | Pos | Pos | — |
| TNF receptor 2 (75 kDa) | — | Pos | — |
| TNF receptor superfamily member 10b (TNFRSF10B) | Pos | — | — |
| STAT1α | — | — | Pos |
| TNF ligand superfamily member 7 (TNFSF7, CD70) | Pos | Pos | — |
| BCL-3 | — | Pos | — |
| TNF-α-induced protein 2 (TNFAIP2) | Pos | Pos | — |
| Phosphatidylinositol 3-kinase, γ-polypeptide | — | Pos | Pos |
| FIP2 TNF-α-inducible protein | Pos | Pos | — |
| A20 | Neg | Neg | — |
Results of microarray analysis of gene expression in NB4 cells treated with 10-6 M ATRA. Fifteen genes previously reported to have been involved in TNF signaling were found to be positively (Pos) or negatively (Neg) regulated at least 2.5-fold by ATRA.
— indicates no change detected.