Summary of activities of HOX11 mutants
Construct . | Mutation . | Repression* . | Aldh-1 up-regulation . | Immortalization† . |
|---|---|---|---|---|
| HOX11 WT | ++++ | + | + (6/6) | |
| HOX11 D1 | Δ1-50 | ++++ | ± | + (3/3) |
| HOX11 D2 | Δ1-97 | +++ | - | - (0/3) |
| HOX11 D3 | Δ1-119 | ++ | - | - (0/3) |
| HOX11 D4 | Δ1-163 | + | - | - (0/3) |
| HOX11 D5 | Δ1-300 | - | - | - (0/3) |
| HOX11 D6 | Δ261-330 | + | ± | + (4/4) |
| HOX11 D7 | Δ198-330 | - | - | - (0/3) |
| HOX11 M1 | Met202Ile | ++++ | + | + (3/3) |
| HOX11 M2 | Pro200Ala | ++++ | + | + (3/3) |
| HOX11 M3 | Δ150-164 | ++++ | + | + (3/3) |
| HOX11 M4 | Δ160-200 | ++ | ND | ND |
| HOX11 M5 | FPWME→NGSSR | ++++ | + | - (0/2) |
| HOX11 H3d | Δ246-251 | - | - | - (0/3) |
| HOX11 HD | Δ211-260 | - | - | - (0/3) |
| HOX11 Thr47Ile | Thr247Ile | ++++ | - | + (4/4) |
| HOX11 Asn51Ala | Asn251Ala | ++++ | - | - (0/3) |
| HOX11 Lys55Gln | Lys255Gln | +++ | - | - (0/3) |
Construct . | Mutation . | Repression* . | Aldh-1 up-regulation . | Immortalization† . |
|---|---|---|---|---|
| HOX11 WT | ++++ | + | + (6/6) | |
| HOX11 D1 | Δ1-50 | ++++ | ± | + (3/3) |
| HOX11 D2 | Δ1-97 | +++ | - | - (0/3) |
| HOX11 D3 | Δ1-119 | ++ | - | - (0/3) |
| HOX11 D4 | Δ1-163 | + | - | - (0/3) |
| HOX11 D5 | Δ1-300 | - | - | - (0/3) |
| HOX11 D6 | Δ261-330 | + | ± | + (4/4) |
| HOX11 D7 | Δ198-330 | - | - | - (0/3) |
| HOX11 M1 | Met202Ile | ++++ | + | + (3/3) |
| HOX11 M2 | Pro200Ala | ++++ | + | + (3/3) |
| HOX11 M3 | Δ150-164 | ++++ | + | + (3/3) |
| HOX11 M4 | Δ160-200 | ++ | ND | ND |
| HOX11 M5 | FPWME→NGSSR | ++++ | + | - (0/2) |
| HOX11 H3d | Δ246-251 | - | - | - (0/3) |
| HOX11 HD | Δ211-260 | - | - | - (0/3) |
| HOX11 Thr47Ile | Thr247Ile | ++++ | - | + (4/4) |
| HOX11 Asn51Ala | Asn251Ala | ++++ | - | - (0/3) |
| HOX11 Lys55Gln | Lys255Gln | +++ | - | - (0/3) |