Table 3. Ex vivo expansion... | American Society of Hematology

Table 3.

Ex vivo expansion characteristics for study patients

Patient no.	Inoculum viable cells, × 10⁶	Cell expansion harvested cells, × 10⁶	Fold increase	Inoculum CFU-GM, × 10⁵	Harvested CFU-GM, × 10⁵	Fold increase	Inoculum CD 34⁺lin^-, × 10⁶	Harvested CD 34⁺ lin^-, × 10⁶	Fold increase
1*	98.0	418.1	4.3	0.65	102.65	157.7	1.14	0.71	0.63
2	168.7	431.3	2.6	0.49	54.22	111.1	1.57	2.50	1.59
3	151.8	608.8	4.0	0.76	170.70	224.0	0.56	1.28	2.28
4	146.7	1124.7	8.5	2.75	260.27	94.6	2.69	1.75	0.65
5	120.2	177.3	1.5	0.23	14.02	60.1	0.32	0.59	1.80
6*	99.1	255	2.6	0.43	51.54	120.1	0.98	0.54	0.55
7	409.8	1290	3.1	2.87	264.47	92.3	2.91	0.90	0.31
8	282.2	378.9	1.3	0.58	106.00	184.0	2.00	0.87	0.43
9	243.9	250.7	1.0	0.81	98.73	121.6	0.85	1.76	2.06
10	928.0	1919	2.1	2.50	97.06	38.8	16.89	8.06	0.48
11*	48.7	64.5	1.3	0.21	0.99	4.6	NA	0.32	NA
12	348.7	1019.3	2.9	1.35	107.37	79.8	2.09	1.12	0.54
13	206.6	435.5	2.1	1.07	30.72	28.7	1.22	1.44	1.18
14*	40.5	131.1	3.2	0.23	3.41	15.1	0.21	0.07	0.32
15*	73.1	171.7	2.3	0.32	27.74	85.7	0.45	0.09	0.19
16*	61.4	99.9	1.6	0.10	1.57	16.4	1.55	0.45	0.29
17*	96.7	213.8	2.2	0.05	13.14	266.4	0.45	0.04	0.09
18	391.6	938.5	2.4	0.62	15.87	25.4	3.80	3.10	0.82
19	124.4	572.3	4.6	0.70	37.95	54.6	1.94	1.78	0.92
20	533.6	1016.4	1.9	0.88	NA	NA	6.83	0.81	0.12
21	278.3	800.4	2.9	0.85	84.26	98.9	1.00	0.48	0.48
22	84.4	146.8	1.7	0.54	9.59	17.9	0.74	0.19	0.26
23	216.4	378.9	1.8	0.19	24.47	125.6	1.36	0.68	0.50
24*	78.7	396.3	5.0	0.58	18.79	32.4	0.44	0.75	1.71
25	225.8	1174.6	5.2	10.40	203.62	19.6	4.88	7.05	1.44
26	104.1	177.1	1.7	0.51	19.58	38.4	1.06	NA	NA
27	307.1	1391	4.5	1.95	356.38	182.8	1.87	4.59	2.45
28	167.1	354.2	2.1	1.92	NA	NA	2.46	NA	NA
Mean	215.6	587.8	2.9	1.23	84	88.3	2.3	1.6	0.9
Median	159.5	407.2	2.4	0.64	45	82.7	1.4	0.8	0.5
SD	186.2	482.0	1.6	1.96	95	69.9	3.3	2.0	0.7

Patient no.	Inoculum viable cells, × 10⁶	Cell expansion harvested cells, × 10⁶	Fold increase	Inoculum CFU-GM, × 10⁵	Harvested CFU-GM, × 10⁵	Fold increase	Inoculum CD 34⁺lin^-, × 10⁶	Harvested CD 34⁺ lin^-, × 10⁶	Fold increase
1*	98.0	418.1	4.3	0.65	102.65	157.7	1.14	0.71	0.63
2	168.7	431.3	2.6	0.49	54.22	111.1	1.57	2.50	1.59
3	151.8	608.8	4.0	0.76	170.70	224.0	0.56	1.28	2.28
4	146.7	1124.7	8.5	2.75	260.27	94.6	2.69	1.75	0.65
5	120.2	177.3	1.5	0.23	14.02	60.1	0.32	0.59	1.80
6*	99.1	255	2.6	0.43	51.54	120.1	0.98	0.54	0.55
7	409.8	1290	3.1	2.87	264.47	92.3	2.91	0.90	0.31
8	282.2	378.9	1.3	0.58	106.00	184.0	2.00	0.87	0.43
9	243.9	250.7	1.0	0.81	98.73	121.6	0.85	1.76	2.06
10	928.0	1919	2.1	2.50	97.06	38.8	16.89	8.06	0.48
11*	48.7	64.5	1.3	0.21	0.99	4.6	NA	0.32	NA
12	348.7	1019.3	2.9	1.35	107.37	79.8	2.09	1.12	0.54
13	206.6	435.5	2.1	1.07	30.72	28.7	1.22	1.44	1.18
14*	40.5	131.1	3.2	0.23	3.41	15.1	0.21	0.07	0.32
15*	73.1	171.7	2.3	0.32	27.74	85.7	0.45	0.09	0.19
16*	61.4	99.9	1.6	0.10	1.57	16.4	1.55	0.45	0.29
17*	96.7	213.8	2.2	0.05	13.14	266.4	0.45	0.04	0.09
18	391.6	938.5	2.4	0.62	15.87	25.4	3.80	3.10	0.82
19	124.4	572.3	4.6	0.70	37.95	54.6	1.94	1.78	0.92
20	533.6	1016.4	1.9	0.88	NA	NA	6.83	0.81	0.12
21	278.3	800.4	2.9	0.85	84.26	98.9	1.00	0.48	0.48
22	84.4	146.8	1.7	0.54	9.59	17.9	0.74	0.19	0.26
23	216.4	378.9	1.8	0.19	24.47	125.6	1.36	0.68	0.50
24*	78.7	396.3	5.0	0.58	18.79	32.4	0.44	0.75	1.71
25	225.8	1174.6	5.2	10.40	203.62	19.6	4.88	7.05	1.44
26	104.1	177.1	1.7	0.51	19.58	38.4	1.06	NA	NA
27	307.1	1391	4.5	1.95	356.38	182.8	1.87	4.59	2.45
28	167.1	354.2	2.1	1.92	NA	NA	2.46	NA	NA
Mean	215.6	587.8	2.9	1.23	84	88.3	2.3	1.6	0.9
Median	159.5	407.2	2.4	0.64	45	82.7	1.4	0.8	0.5
SD	186.2	482.0	1.6	1.96	95	69.9	3.3	2.0	0.7

NA indicates not assessed.

Indicated cassettes inoculated with fewer than 100 million viable cells