Kinetics of HCMV infection and response to treatment in blood of HSCT recipients of the 2 arms according to different assays
. | No. of positive blood samples/total no. tested (%) in the randomization arm . | . | . | . | |
|---|---|---|---|---|---|
| Blood samples tested . | IEmRNA . | Antigenemia . | P . | Total no. (%) . | |
| After transplantation | |||||
| IEmRNA | 238/868 (27.4) | 149/687 (21.7) | .009 | 387/1555 (24.9) | |
| Antigenemia | 187/861 (21.7) | 109/724 (15.1) | .001 | 296/1585 (18.7) | |
| DNAemia | 145/838 (17.3) | 84/687 (12.2) | .006 | 229/1525 (15.0) | |
| Before therapy | |||||
| IEmRNA | 71/442 (16.1) | 66/451 (14.6) | NS | 137/893 (15.3) | |
| Antigenemia | 40/435 (9.2)* | 34/469 (7.2)* | NS | 74/904 (8.2) | |
| DNAemia | 37/430 (8.6)* | 33/452 (7.3)* | NS | 70/882 (7.9) | |
| During therapy | |||||
| IEmRNA | 97/220 (44.1)* | 40/104 (38.5)* | NS | 137/324 (42.3) | |
| Antigenemia | 103/220 (46.8)* | 50/117 (42.7)* | NS | 153/337 (45.4) | |
| DNAemia | 65/211 (30.8) | 27/104 (26.0) | NS | 92/315 (29.2) | |
. | No. of positive blood samples/total no. tested (%) in the randomization arm . | . | . | . | |
|---|---|---|---|---|---|
| Blood samples tested . | IEmRNA . | Antigenemia . | P . | Total no. (%) . | |
| After transplantation | |||||
| IEmRNA | 238/868 (27.4) | 149/687 (21.7) | .009 | 387/1555 (24.9) | |
| Antigenemia | 187/861 (21.7) | 109/724 (15.1) | .001 | 296/1585 (18.7) | |
| DNAemia | 145/838 (17.3) | 84/687 (12.2) | .006 | 229/1525 (15.0) | |
| Before therapy | |||||
| IEmRNA | 71/442 (16.1) | 66/451 (14.6) | NS | 137/893 (15.3) | |
| Antigenemia | 40/435 (9.2)* | 34/469 (7.2)* | NS | 74/904 (8.2) | |
| DNAemia | 37/430 (8.6)* | 33/452 (7.3)* | NS | 70/882 (7.9) | |
| During therapy | |||||
| IEmRNA | 97/220 (44.1)* | 40/104 (38.5)* | NS | 137/324 (42.3) | |
| Antigenemia | 103/220 (46.8)* | 50/117 (42.7)* | NS | 153/337 (45.4) | |
| DNAemia | 65/211 (30.8) | 27/104 (26.0) | NS | 92/315 (29.2) | |
NS indicates not significant.
All statistical comparisons between the 2 guiding assays (performed in vertical within each arm and each group of data) by the chi-square test showed statistically significant differences (P < .05), except for the 4 pairs of comparisons marked with asterisks.