IgH and IgL gene rearrangement data from the 31 analyzed VH3-21 positive cases
Case no. . | VH homology, % . | D gene . | JH gene . | VH reading frame . | Vκ family† . | Vλ . | VL gene homology, % . | Jλ/κ . | VL gene reading frame* . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 99.1 | — | 6 | F | 2 | 2-14 | 98.4 | 3 | F |
| 2 | 98.2 | — | 6 | F | 2 & 4 | 2-14 | 97.2 | 3 | F |
| 3 | 96.9 | — | 6 | F | 1 | 2-14 & 2-11 | 98.4 & 98.7 | 3 & 3 | F & NF |
| 4 | 96.4 | — | 6 | F | 1 | 2-14 | 97.6 | 3 | F |
| 5 | 97.8 | — | 6 | F | Vκ2 A18 | — | 100 | 4 | NF |
| 6 | 95.9 | — | 6 | F | 3 | 2-14 | 98 | 3 | F |
| 7 | 95.9 | — | 6 | F | 2 | 2-14 | 98.8 | 3 | F |
| 8 | 97.3 | — | 6 | F | — | 2-14 | 96.9 | 3 | F |
| 9 | 96.4 | — | 6 | F | 1 & 4 | 2-14 | 98 | 3 | F |
| 10 | 96.4 | — | 6 | F | 1 & 3 | 2-14 | 89.4 | 3 | F |
| 11 | 97.3 | — | 6 | F | — | 2-14 | 98.4 | 3 | F |
| 12 | 96.4 | — | 6 | F | — | 2-14 | 99.6 | 3 | F |
| 13 | 99.1 | — | 6 | F | 3 & 4 | 2-14 | 98 | 3 | F |
| 14 | 99.6 | — | 6 | F | 2 & 4 | 2-14 | 98.4 | 3 | F |
| 15 | 95.9 | — | 6 | F | 4 | 2-14 | 98 | 3 | F |
| 16 | 96.4 | — | 6 | F | 1 | 2-14 | 98.4 | 3 | F |
| 17 | 99.1 | — | 6 | F | 4 | 2-14 | 98.4 | 3 | F |
| 18 | 100 | — | 6 | F | 1 | 2-14 | 99.2 | 3 | F |
| 19 | 95.1 | — | 6 | F | — | 2-14 | 98.4 | 3 | F |
| 20 | 95.9 | — | 6 | F | 3 | 3-4 | 96.3 | 3 | NF |
| 21 | 96.9 | — | 6 | F | 1 | 2-14 | 99.2 | 3 | F |
| 22 | 97.3 | 3-22 | 4 | F | 1 | 2-14 & 1-3 | 97.6 & 91.9 | 3 & 3 | F & NF |
| 23 | 95.1 | 5-5/5-18 | 3 | F | — | 2-14 | 97.6 | 3 | F |
| 24 | 97.3 | 6-13 | 4 | F | 1 | 2-14 | 98.4 | 3 | F |
| 25 | 94.2 | 2-2 | 3 | F | 3 | 2-14 | 98.8 | 1 | F |
| 26 | 96.4 | — | 4 | F | 1 | 2-14 & 1-17 | 98.8 & 97.6 | 3 & 1 | Both F |
| 27 | 100 | 6-19 | 4 | F | 1 | 2-11 | 100 | 1 | F |
| 28 | 100 | 6-13 | 6 | F | Vκ3 A27 & Vκ1 L12 | — | 100 & 100 | 1 & 1 | F & NF |
| 29 | 100 | 3-10 | 6 | F | Vκ3 L2 | — | 100 | 2 | F |
| 30 | 100 | 3-3 | 6 | F | Vκ1 L12 | — | 100 | 1 | F |
| 31 | 92.8 | 1-7 | 6 | NF | 2 & 5/6 | 1-4 | 98.6 | 1 | F |
Case no. . | VH homology, % . | D gene . | JH gene . | VH reading frame . | Vκ family† . | Vλ . | VL gene homology, % . | Jλ/κ . | VL gene reading frame* . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 99.1 | — | 6 | F | 2 | 2-14 | 98.4 | 3 | F |
| 2 | 98.2 | — | 6 | F | 2 & 4 | 2-14 | 97.2 | 3 | F |
| 3 | 96.9 | — | 6 | F | 1 | 2-14 & 2-11 | 98.4 & 98.7 | 3 & 3 | F & NF |
| 4 | 96.4 | — | 6 | F | 1 | 2-14 | 97.6 | 3 | F |
| 5 | 97.8 | — | 6 | F | Vκ2 A18 | — | 100 | 4 | NF |
| 6 | 95.9 | — | 6 | F | 3 | 2-14 | 98 | 3 | F |
| 7 | 95.9 | — | 6 | F | 2 | 2-14 | 98.8 | 3 | F |
| 8 | 97.3 | — | 6 | F | — | 2-14 | 96.9 | 3 | F |
| 9 | 96.4 | — | 6 | F | 1 & 4 | 2-14 | 98 | 3 | F |
| 10 | 96.4 | — | 6 | F | 1 & 3 | 2-14 | 89.4 | 3 | F |
| 11 | 97.3 | — | 6 | F | — | 2-14 | 98.4 | 3 | F |
| 12 | 96.4 | — | 6 | F | — | 2-14 | 99.6 | 3 | F |
| 13 | 99.1 | — | 6 | F | 3 & 4 | 2-14 | 98 | 3 | F |
| 14 | 99.6 | — | 6 | F | 2 & 4 | 2-14 | 98.4 | 3 | F |
| 15 | 95.9 | — | 6 | F | 4 | 2-14 | 98 | 3 | F |
| 16 | 96.4 | — | 6 | F | 1 | 2-14 | 98.4 | 3 | F |
| 17 | 99.1 | — | 6 | F | 4 | 2-14 | 98.4 | 3 | F |
| 18 | 100 | — | 6 | F | 1 | 2-14 | 99.2 | 3 | F |
| 19 | 95.1 | — | 6 | F | — | 2-14 | 98.4 | 3 | F |
| 20 | 95.9 | — | 6 | F | 3 | 3-4 | 96.3 | 3 | NF |
| 21 | 96.9 | — | 6 | F | 1 | 2-14 | 99.2 | 3 | F |
| 22 | 97.3 | 3-22 | 4 | F | 1 | 2-14 & 1-3 | 97.6 & 91.9 | 3 & 3 | F & NF |
| 23 | 95.1 | 5-5/5-18 | 3 | F | — | 2-14 | 97.6 | 3 | F |
| 24 | 97.3 | 6-13 | 4 | F | 1 | 2-14 | 98.4 | 3 | F |
| 25 | 94.2 | 2-2 | 3 | F | 3 | 2-14 | 98.8 | 1 | F |
| 26 | 96.4 | — | 4 | F | 1 | 2-14 & 1-17 | 98.8 & 97.6 | 3 & 1 | Both F |
| 27 | 100 | 6-19 | 4 | F | 1 | 2-11 | 100 | 1 | F |
| 28 | 100 | 6-13 | 6 | F | Vκ3 A27 & Vκ1 L12 | — | 100 & 100 | 1 & 1 | F & NF |
| 29 | 100 | 3-10 | 6 | F | Vκ3 L2 | — | 100 | 2 | F |
| 30 | 100 | 3-3 | 6 | F | Vκ1 L12 | — | 100 | 1 | F |
| 31 | 92.8 | 1-7 | 6 | NF | 2 & 5/6 | 1-4 | 98.6 | 1 | F |