DLA-identical marrow grafts after conditioning with 213Bi-anti-TCRαβ
Dog no. . | Dog weight, kg . | Anti-TCRαβ mAb mg/kg . | 213Bi mCi/kg (MBq/kg) . | Marrow MNCs × 108/kg . | GVHD . | % Donor chimerism in MNCs . | Survival, wks* . |
|---|---|---|---|---|---|---|---|
| E974 | 9.6 | 0.46 | 4.5 (167) | 5.0 | No | 3-15 | > 40 |
| E986 | 9.0 | 0.17 | 5.6 (207) | 3.5 | No | 10-40 | > 40 |
| E979 | 10.7 | 0.13 | 4.7 (174) | 5.3 | No | 40-60 | > 40 |
| G110 | 6.0 | 0.13 | 3.7 (137) | 7.6 | No | 20-45 | > 35 |
Dog no. . | Dog weight, kg . | Anti-TCRαβ mAb mg/kg . | 213Bi mCi/kg (MBq/kg) . | Marrow MNCs × 108/kg . | GVHD . | % Donor chimerism in MNCs . | Survival, wks* . |
|---|---|---|---|---|---|---|---|
| E974 | 9.6 | 0.46 | 4.5 (167) | 5.0 | No | 3-15 | > 40 |
| E986 | 9.0 | 0.17 | 5.6 (207) | 3.5 | No | 10-40 | > 40 |
| E979 | 10.7 | 0.13 | 4.7 (174) | 5.3 | No | 40-60 | > 40 |
| G110 | 6.0 | 0.13 | 3.7 (137) | 7.6 | No | 20-45 | > 35 |
MNC indicates mononuclear cells.
All dogs were euthanized on completion of the study.