Table 1.

Radiation-absorbed doses projected for 213Bi—anti-TCRαβ mAb from the 111In—anti-TCRαβ mAb biodistribution data in dog E886 (weight 10.4 kg)


Organ or tissue

Absorbed dose, cGy/mCi 213Bi administered
Lungs   11.6  
Liver   8.24  
Spleen   30.4  
Heart*  14.6  
Blood   9.12  
Marrow   13.7  
Total body
 
1.67
 

Organ or tissue

Absorbed dose, cGy/mCi 213Bi administered
Lungs   11.6  
Liver   8.24  
Spleen   30.4  
Heart*  14.6  
Blood   9.12  
Marrow   13.7  
Total body
 
1.67
 
*

Dose estimate includes activity in blood pool.

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