Ability of different MAP kinase kinases (MAPKKs) to phosphorylate/activate Map kinases from different groups
. | Mkk1 . | Mkk2 . | Mkk3 . | Mkk4 . | Mkk5 . | Mkk6 . | Mkk7 . |
|---|---|---|---|---|---|---|---|
| Motif | Thr-Glu-Tyr | Thr-Glu-Tyr | Thr-Gly-Tyr | Thr-Gly-Tyr, Thr-Pro-Tyr | Thr-Glu-Tyr | Thr-Gly-Tyr | Thr-Pro-Tyr |
| Erk | + | + | - | - | - | - | - |
| p38 | - | - | + | + | - | + | - |
| JNK | - | - | - | + | - | - | + |
| Erk5 | - | - | - | - | + | - | - |
. | Mkk1 . | Mkk2 . | Mkk3 . | Mkk4 . | Mkk5 . | Mkk6 . | Mkk7 . |
|---|---|---|---|---|---|---|---|
| Motif | Thr-Glu-Tyr | Thr-Glu-Tyr | Thr-Gly-Tyr | Thr-Gly-Tyr, Thr-Pro-Tyr | Thr-Glu-Tyr | Thr-Gly-Tyr | Thr-Pro-Tyr |
| Erk | + | + | - | - | - | - | - |
| p38 | - | - | + | + | - | + | - |
| JNK | - | - | - | + | - | - | + |
| Erk5 | - | - | - | - | + | - | - |
Mkk indicates Map kinase kinase; Erk, extracellular signal-regulated kinase; JNK, c-Jun NH2-terminal kinase; +, specified Map kinase is phosphorylated/activated by the specified Mkk; and -, specified Map kinase is not a known substrate for the specified Mkk.