Table 1. TA99-mediated protection from... | American Society of Hematology

Table 1.

TA99-mediated protection from melanoma metastases in secondary target organs is dependent on Mac-1

	Lymph nodes		Liver/spleen	Kidney	CNS
	Thoracic	Abdominal	Liver/spleen	Kidney	CNS
WT saline	1.43 ± 0.46	1.57 ± 0.32	0.71 ± 0.31	0.86 ± 0.15	1.86 ± 0.15
WT TA99	0	0.43 ± 0.32	0	0	0.43 ± 0.32
Mac-1^−/−saline	1.33 ± 0.37	1.33 ± 0.37	0.67 ± 0.37	0.50 ± 0.24	0.33 ± 0.23
Mac-1^−/−TA99	0.67 ± 0.37	1.33 ± 0.46	0.17 ± 0.18	0	0.50 ± 0.37

	Lymph nodes		Liver/spleen	Kidney	CNS
	Thoracic	Abdominal	Liver/spleen	Kidney	CNS
WT saline	1.43 ± 0.46	1.57 ± 0.32	0.71 ± 0.31	0.86 ± 0.15	1.86 ± 0.15
WT TA99	0	0.43 ± 0.32	0	0	0.43 ± 0.32
Mac-1^−/−saline	1.33 ± 0.37	1.33 ± 0.37	0.67 ± 0.37	0.50 ± 0.24	0.33 ± 0.23
Mac-1^−/−TA99	0.67 ± 0.37	1.33 ± 0.46	0.17 ± 0.18	0	0.50 ± 0.37

WT and Mac-1^−/− mice were challenged with 1 × 10⁵ B16F10 melanoma cells and treated with saline or TA99 combined with peg–G-CSF. Secondary target organs (thoracic and abdominal lymph nodes, liver, spleen, kidney, and CNS) were analyzed for presence of metastases on day 21. Results represent mean numbers (± SEMs) of metastases per target organ (WT: n = 7; Mac-1^−/−: n = 6).

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