Characteristics of HES patients with increased and normal tryptase levels
Patient group . | Serum tryptase level 11.5 ng/mL or greater . | Serum tryptase level less than 11.5 ng/mL . | P . |
|---|---|---|---|
| Number of patients | 9 | 6 | |
| Median age, y (range) | 38 (28-77) | 36 (17-57) | NS |
| Sex, M/F | 9/0 | 1/5 | < .01 |
| WBC, × 109/L, median (range) | 18.1 (13.3-31.6) | 8.2 (6.2-16.4) | .04 |
| Eosinophils, × 109/L, median (range) | 8.352 (2.425-27.550) | 1.792 (.707-6.216) | < .01 |
| Basophils, × 109/L, median (range) | .001 (0-.072) | .026 (.009-.057) | NS |
| Splenomegaly | 7/9 | 0/6 | < .01 |
| Myeloid precursors on peripheral smear | 8/9 | 0/6 | < .01 |
| Bone marrow biopsy cellularity, greater than 50% | 7/9 | 1/4 | NS |
| Dysplastic mast cells* | 7/9 | 0/4 | .02 |
| Myelofibrosis† | 5/9 | 0/4 | NS |
| Median hemoglobin, g/dL (range) | 12.2 (6.9-13.8) | 13.8 (11-15) | .08 |
| Median platelet count, 109/L (range) | 165 (95-223) | 283 (192-531) | < .01 |
| Median serum IgE level, kU/L (range) | 15 (0-4862) | 137 (11-544) | .08 |
| Median serum B12 level, pM (range) | 4255 (2315-20 316) | 592 (276-838) | < .01 |
Patient group . | Serum tryptase level 11.5 ng/mL or greater . | Serum tryptase level less than 11.5 ng/mL . | P . |
|---|---|---|---|
| Number of patients | 9 | 6 | |
| Median age, y (range) | 38 (28-77) | 36 (17-57) | NS |
| Sex, M/F | 9/0 | 1/5 | < .01 |
| WBC, × 109/L, median (range) | 18.1 (13.3-31.6) | 8.2 (6.2-16.4) | .04 |
| Eosinophils, × 109/L, median (range) | 8.352 (2.425-27.550) | 1.792 (.707-6.216) | < .01 |
| Basophils, × 109/L, median (range) | .001 (0-.072) | .026 (.009-.057) | NS |
| Splenomegaly | 7/9 | 0/6 | < .01 |
| Myeloid precursors on peripheral smear | 8/9 | 0/6 | < .01 |
| Bone marrow biopsy cellularity, greater than 50% | 7/9 | 1/4 | NS |
| Dysplastic mast cells* | 7/9 | 0/4 | .02 |
| Myelofibrosis† | 5/9 | 0/4 | NS |
| Median hemoglobin, g/dL (range) | 12.2 (6.9-13.8) | 13.8 (11-15) | .08 |
| Median platelet count, 109/L (range) | 165 (95-223) | 283 (192-531) | < .01 |
| Median serum IgE level, kU/L (range) | 15 (0-4862) | 137 (11-544) | .08 |
| Median serum B12 level, pM (range) | 4255 (2315-20 316) | 592 (276-838) | < .01 |