Hematologic parameters of Prx II-/- mice
Mice . | No. . | WBC, 103/μL . | RBC, 106/μL . | HB,* g/dL . | HCT,* % . | MCV, fL . | Reticulocytes, †§ % . | Na+, mM‡ . | K+, mM‡ . | Spleen weight, † SW/BW§ . |
|---|---|---|---|---|---|---|---|---|---|---|
| Prx II+/+ | 14 | 5.1 ± 2.5 | 10.4 ± 0.6 | 16.5 ± 0.9 | 54.4 ± 3.1 | 52.0 ± 2.6 | 1.8 ± 0.7 | 26.5 ± 3.9 | 98.9 ± 6.9 | 0.002 ± 0.0002 |
| Prx II-/- | 18 | 5.7 ± 2.9 | 9.3 ± 0.9 | 14.7 ± 1.5 | 48.8 ± 5.8 | 52.2 ± 2.4 | 3.5 ± 1.0 | 31.7 ± 4.8 | 105.4 ± 1.7 | 0.003 ± 0.0003 |
Mice . | No. . | WBC, 103/μL . | RBC, 106/μL . | HB,* g/dL . | HCT,* % . | MCV, fL . | Reticulocytes, †§ % . | Na+, mM‡ . | K+, mM‡ . | Spleen weight, † SW/BW§ . |
|---|---|---|---|---|---|---|---|---|---|---|
| Prx II+/+ | 14 | 5.1 ± 2.5 | 10.4 ± 0.6 | 16.5 ± 0.9 | 54.4 ± 3.1 | 52.0 ± 2.6 | 1.8 ± 0.7 | 26.5 ± 3.9 | 98.9 ± 6.9 | 0.002 ± 0.0002 |
| Prx II-/- | 18 | 5.7 ± 2.9 | 9.3 ± 0.9 | 14.7 ± 1.5 | 48.8 ± 5.8 | 52.2 ± 2.4 | 3.5 ± 1.0 | 31.7 ± 4.8 | 105.4 ± 1.7 | 0.003 ± 0.0003 |
WBC indicates white blood cells; RBC, red blood cells; HB, hemoglobin; HCT, hematocrit; MCV, mean cell volume; SW/BW, spleen weight per body weight in each mouse; Prx II+/+, SVJ129 inbred mice. The data were statistically analyzed by t test; *P < .05; †P < .0001.
RBC cation determinations were performed on control (n = 3) and Prx II—deficient (n = 3) mice.
The reticulocyte count and spleen weights were performed on control (n = 10) and Prx II—deficient (n = 10) mice.