Table 1. Laboratory findings in 7... | American Society of Hematology

Table 1.

Laboratory findings in 7 patients with an inhibitor to factor XI

Patient*†	Sex/age, y	aPTT, sec	Level of inhibitor, Bethesda units	Circumstances at detection	No. exposures to plasma
1	M/77	99	25	Bleeding	1
2	F/77	97	16	Screening	3
3	M/64	> 110	4	Bleeding	1
4	M/68	> 110	4	Screening	4
5	M/87	> 110	4	Bleeding	3
6	M/54	> 110	4	Screening	10
7	M/51	> 110	3‡	Screening	2

Patient*†	Sex/age, y	aPTT, sec	Level of inhibitor, Bethesda units	Circumstances at detection	No. exposures to plasma
1	M/77	99	25	Bleeding	1
2	F/77	97	16	Screening	3
3	M/64	> 110	4	Bleeding	1
4	M/68	> 110	4	Screening	4
5	M/87	> 110	4	Bleeding	3
6	M/54	> 110	4	Screening	10
7	M/51	> 110	3‡	Screening	2

All patients were of the II/II genotype; II indicates an allele carrying type II (Glu117Stop) mutation in the factor XI gene.

All patients had less than 1 U/dL factor XI activity.

This titer was detected 3 years earlier; during the study, no inhibitory activity was detectable.